Serum or Plasma Substance Concentration (Bromocresol Green Dye Binding)

What Does This Test Measure?

The test uses bromocresol green dye, a chemical that binds to proteins in your blood. When mixed with serum or plasma, the dye’s ability to bind changes based on protein concentration, particularly albumin. This change is measured to estimate protein levels or liver function indirectly.

Why Might You Need This Test?

Your healthcare provider may order this test if you have symptoms like jaundice, unexplained weight loss, fatigue, or if they suspect liver disease, protein deficiency, or other conditions affecting protein synthesis or liver function.

How Is the Test Performed?

A blood sample is drawn from a vein, typically in your arm. The sample is sent to a lab where it’s mixed with bromocresol green dye. The dye’s binding capacity is then measured to determine protein-related metrics.

What Are Common Uses?

This test is less commonly used today but historically helped diagnose liver conditions (like cirrhosis), protein disorders, or assess albumin levels in certain clinical scenarios. Modern tests often replace it with more specific protein or liver function tests.