Serum or plasma concentration of digestive enzymes (specifically, amylase and lipase combined or individually measured)

Why This Test Is Done

Your doctor may order this test if you have symptoms like abdominal pain, nausea, vomiting, or unexplained weight loss. It can also be part of routine checks for conditions like pancreatitis, cystic fibrosis, or other digestive disorders. Sometimes, it’s used to monitor treatment progress or detect early signs of organ damage.

What to Expect Before the Test

No special preparation is usually needed, but you may be asked to fast for 8–12 hours before the test if it involves blood drawn from a vein. If you’re taking certain medications, let your doctor know. Avoid heavy meals or alcohol before the test to get more accurate results.

What Happens During the Test

A healthcare professional will draw blood from a vein in your arm using a small needle. You may feel a slight pinch, but it’s usually over quickly. The blood sample is then sent to a lab for analysis. If this test involves urine or saliva, you’ll collect a sample at home or in a clinic.

What the Results Mean

High levels of digestive enzymes may indicate inflammation, infection, or damage to the pancreas or other organs. Low levels could suggest a blockage or other digestive issues. Your doctor will interpret results in the context of your symptoms and medical history.