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Serum or plasma concentration of total protein by nephelometry (or turbidimetry)

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein in your blood, which includes albumin and other proteins like globulins. Proteins help maintain fluid balance, support immune function, and transport nutrients.

Quick summary

["Total protein levels can indicate overall health, hydration status, or potential protein-related conditions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
76592-5
Short code
S aureus sau3AI XXX.tiss NAA+probe
Synonyms
S aureus sau3AI XXX.tiss NAA+probe
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test to check for conditions like malnutrition, kidney disease, liver problems, or dehydration. It can also help monitor treatment responses for certain conditions.

What to Expect Before the Test

No special preparation is needed. You may have a small needle inserted into your arm or vein to draw blood. If you’re on blood thinners, let your provider know before the test.

What the Results Mean

Higher-than-normal levels might suggest dehydration, inflammation, or conditions like multiple myeloma. Lower-than-normal levels could indicate malnutrition, liver or kidney disease, or excessive protein loss.

Common Conditions Monitored

This test is often used to assess protein balance in cases of chronic kidney disease, liver cirrhosis, or severe infections. It can also help diagnose or monitor conditions like nephrotic syndrome.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Total protein levels can reflect underlying health issues, such as protein loss due to kidney or liver dysfunction, or fluid imbalances. Abnormal results may prompt further testing to identify the cause.

Short name

Total Protein

Frequently asked questions

What causes total protein levels to be too high?
High total protein levels may be due to dehydration, chronic inflammation, or conditions like multiple myeloma or severe infections. Your provider will discuss possible causes based on your medical history and symptoms.
What causes total protein levels to be too low?
Low total protein levels can result from malnutrition, liver or kidney disease, or conditions causing excessive protein loss (e.g., kidney disease, severe burns). Dietary changes or medical treatments may be recommended if needed.
How often should I get this test?
Frequency depends on your health condition and provider’s recommendations. Some people get it once a year, while others may need it more often if they have ongoing health issues like kidney or liver disease.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy