Understanding Your Laboratory Test: What Patients Need to Know
This test detects the presence of Toxic Shock Syndrome Toxin 1 (TSST-1) produced by Staphylococcus aureus bacteria in your blood sample.
{"TSST-1 is a toxin produced by certain Staphylococcus aureus bacteria","This test helps diagnose Toxic Shock Syndrome (TSS), a serious condition","Results are reported as Detected or Not Detected","Early detection is crucial for prompt treatment"}
Key facts at a glance
- LOINC
- 23935-0
- Short code
- TSST-1
- Synonyms
- S aureus TSST-1 Spec Ql
- Category
- cardiac
- Sample
- serum
- Container
- Serum separator tube (SST) or plain red top tube
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 0–120 years
- Method
- Enzyme-linked immunosorbent assay (ELISA) or chemiluminescent immunoassay (CLIA) for qualitative detection of TSST-1
- CPT
- 86635
- SNOMED
- 40930008
- Specimen volume
- 1-2 mL of serum minimum
- Stability
- Room temperature: 8 hours; Refrigerated (2-8°C): 72 hours; Frozen (-20°C or below): 30 days
- Hemolysis max
- 50
- Lipemia max
- 100
- Icterus max
- 20
- TAT
- 24–72 hours
- Order
- routine
This is a diagnostic test that gives your healthcare provider important information about how your body is working. By examining a sample or taking a simple measurement, the test helps show whether certain conditions are present and provides results that guide your care.
The Toxic Shock Syndrome Toxin 1 (TSST-1) test is a laboratory test that looks for the presence of a specific toxin called TSST-1 in your blood (serum). This toxin is produced by certain strains of Staphylococcus aureus bacteria and is the primary cause of Toxic Shock Syndrome (TSS), a rare but potentially life-threatening condition.
Your doctor may order this test to find out what is causing your symptoms, to confirm or rule out a suspected condition, or as part of a routine checkup. The results can also help monitor an ongoing condition or check how well a treatment is working, so your care team can make well-informed decisions.
Your healthcare provider may order this test if you have symptoms suggestive of Toxic Shock Syndrome, which include high fever, rash, low blood pressure, and involvement of multiple organ systems. This test helps confirm whether TSST-1-producing bacteria are present in your body.
The test is usually done in a doctor's office, clinic, or laboratory by a trained member of your care team. Depending on the type of test, a small sample of blood, urine, or other material may be collected, or a simple noninvasive measurement may be taken. The procedure is typically quick, and your provider will let you know if any preparation is needed beforehand.
A blood sample will be drawn from a vein in your arm. The sample is then sent to a laboratory where it is analyzed using specialized techniques to detect the presence of TSST-1 toxin. The test is qualitative, meaning it reports whether the toxin is detected or not detected, rather than a numerical value.
Reference range
Not detected / NegativeN/A
No special preparation required. Collect serum using standard venipuncture technique. Avoid hemolysis. Inform clinician of any recent antibiotic use as this may affect results.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Detection of TSST-1 is highly suggestive of Toxic Shock Syndrome, a condition that requires immediate medical attention. TSS can occur in various situations, including in individuals with nasopharyngeal colonization of TSST-1-producing S. aureus, in patients with deep tissue infections, or in women during menstruation (historically associated with high-absorbency tampon use). Prompt diagnosis and treatment with appropriate antibiotics and supportive care are essential for favorable outcomes.
Frequently asked questions
Is this test painful?
How long does it take to get results?
What do the results mean?
Do I need to prepare for the test?
Sources
- 1
- 2
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 10, 2026. · Read our editorial policy