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Serum Creatinine and Digoxin Total Concentration Ratio (or Combined Measurement)

Published: August 9, 2026Updated: August 16, 2026

This test measures your creatinine level and evaluates total digoxin (a heart medication) in your blood. It helps assess kidney function and potential drug toxicity.

Quick summary

["Checks kidney health and digoxin levels to prevent dangerous side effects."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
61320-8
Short code
Scad IgE/IgE total %
Synonyms
Scad IgE/IgE total %
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Matters

Creatinine is a waste product from muscle metabolism that kidneys filter out. High levels may indicate kidney problems. Digoxin is used to treat heart conditions but can be toxic if too much is present. This test helps doctors monitor both safely.

What to Expect Before the Test

No special preparation is needed. You’ll have a simple blood draw, usually from your arm. If you’re on digoxin, your doctor may adjust timing to avoid interference with test results.

What the Results Mean

Results are interpreted by your healthcare provider based on your medical history and other lab values. Elevated creatinine may signal kidney strain, while abnormal digoxin levels could require dose adjustments.

Common Causes of Abnormal Results

Kidney disease (elevated creatinine) or digoxin overdose (high total digoxin) can cause abnormal results. Other factors like dehydration or recent heart conditions may also play a role.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Creatinine-Digoxin Ratio (or Serum Digoxin Screening)

Frequently asked questions

What might trigger this test?
Your doctor may order this test if you’re on digoxin, have kidney concerns, or have symptoms like nausea, irregular heartbeat, or fatigue that could relate to both kidney function and heart issues.
How often should I expect this test?
Frequency depends on your treatment plan. If you’re stable, it may be checked annually or less often. If you have kidney issues or digoxin, your doctor may schedule more frequent tests.
Can I drink water before this test?
Yes, but avoid excessive fluid intake 24 hours before if your creatinine is being measured to avoid misleading results. Follow your doctor’s specific instructions.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy