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Staphylococcus aureus **Methicillin Resistance Detection (PCR-based, whole blood specimen)**

Published: August 9, 2026Updated: August 17, 2026

This test checks for the presence of genes linked to methicillin-resistant *Staphylococcus aureus* (MRSA) bacteria in your blood. MRSA is a type of staph infection that can be harder to treat with certain antibiotics.

Quick summary

MRSA can cause serious infections, so early detection helps guide treatment choices.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
86622-8
Short code
SCCmec + mecA+mecC pnl Nose
Synonyms
SCCmec + mecA+mecC pnl Nose
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
0
Ref high
2
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

The test looks for specific genetic markers (genes) that indicate whether your blood contains bacteria resistant to common antibiotics like methicillin. These markers are detected using a **PCR (polymerase chain reaction)** method, which amplifies tiny amounts of bacterial DNA to identify the presence of MRSA.

Why It Matters in Your Care

If MRSA is found, your healthcare provider may adjust your treatment plan to use antibiotics that are more effective against MRSA, reducing the risk of complications or treatment failure.

Sample Collection and Preparation

This test uses a **whole blood sample** collected during a standard blood draw. The sample is processed to extract genetic material (DNA) from any present bacteria, which is then analyzed for MRSA-specific genes.

When You Might Need This Test

Your doctor may order this test if you have symptoms of a staph infection (such as fever, redness, or pain), have been exposed to MRSA, or if you’re at higher risk (e.g., hospital stays, certain medical devices). It’s also used in screening for healthcare-associated infections.

Reference range

NCBI: SCC <2.0 ng/mLN/A

Specimen: serum

No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

MRSA Detection (PCR)

Frequently asked questions

How Does This Test Help Healthcare Providers?
This test provides rapid confirmation of MRSA presence, allowing for targeted antibiotic therapy. MRSA is a growing concern in hospitals and communities, and early detection helps prevent spread and reduces antibiotic resistance.
What Are the Limitations?
While highly sensitive, this test only detects MRSA genes. It does not confirm active infection or rule out other bacteria. Results should be interpreted alongside clinical symptoms and other diagnostic tests.
What If My Results Are Positive?
If positive, follow your doctor’s treatment plan carefully. This may include specific antibiotics, isolation precautions, or additional monitoring. Avoid sharing personal items (like towels) to prevent spreading MRSA.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy