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Genetic analysis for SDHB gene mutations (full sequencing)

Published: August 9, 2026Updated: August 16, 2026

This test checks for changes (mutations) in the SDHB gene, which may be linked to certain inherited cancers or other health conditions.

Quick summary

["Helps identify inherited risks for cancer or related disorders by examining gene mutations."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
82530-7
Short code
SDHB gene Del+Dup + Full Mut Anl Bld/T
Synonyms
SDHB gene Del+Dup + Full Mut Anl Bld/T
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
molgen
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have a family history of certain cancers (such as paraganglioma, pheochromocytoma, or renal cell carcinoma), or if you have symptoms or a diagnosis related to these conditions. It can also be part of genetic counseling for individuals at higher risk.

What to Expect Before the Test

No special preparation is needed for this test. A blood sample will be taken from a vein in your arm. You may feel a brief pinch, but it usually doesn’t cause discomfort. If you’re taking blood thinners, inform your provider beforehand.

What the Results Mean

Results can be normal (no mutations detected) or positive (mutations found). A positive result means you carry a genetic change in the SDHB gene, which may increase your risk for specific cancers or other health issues. Results are discussed with your healthcare provider in the context of your medical history.

Possible Outcomes and Next Steps

If a mutation is found, your provider may recommend additional testing, monitoring, or lifestyle adjustments to manage risk. If no mutation is detected, your risk may be lower, but ongoing medical care is still important.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Mutations in the SDHB gene are associated with inherited conditions like hereditary paraganglioma-pheochromocytoma syndrome (HPP), which can lead to tumors in certain organs. Early detection can help guide preventive measures, such as regular screenings or monitoring for symptoms.

Short name

SDHB Gene Mutation Test

Frequently asked questions

Will this test show all possible mutations?
This test checks for specific mutations in the SDHB gene using full sequencing. It may not detect all possible genetic variations or mutations in other genes related to similar conditions. Additional testing may be needed if your provider suspects other genetic factors.
What if I have a family history of these cancers?
If you have a family history, this test can help determine if the condition is inherited. It may help clarify your risk and guide decisions about genetic counseling, testing for family members, or preventive care.
How long will it take to get results?
Results typically take several weeks to months, depending on lab processes and genetic analysis. Your provider will contact you once results are ready, and they will explain what they mean for your health.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy