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Succinate Dehydrogenase (SDH) Activity in Blood

Published: August 9, 2026Updated: August 16, 2026

This test measures the activity level of succinate dehydrogenase, an enzyme involved in cellular energy production. It may be used to evaluate mitochondrial function or assess genetic conditions affecting enzyme activity.

Quick summary

["SDH activity helps diagnose or monitor conditions linked to mitochondrial or enzyme deficiencies."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
38911-4
Short code
SDHC gene Mut Anl Bld/T
Synonyms
SDHC gene Mut Anl Bld/T
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Ref low
0
Ref high
5
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
molgen
CPT
84702
SNOMED
275917004
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test if you have symptoms or a family history suggesting mitochondrial disorders, metabolic diseases, or genetic mutations affecting energy production. It can also be part of broader evaluations for unexplained fatigue, muscle weakness, or developmental delays.

What Does the Test Involve?

A blood sample is collected from a vein in your arm. The sample is then processed to measure the enzyme’s activity level. Results are typically reported as a ratio or relative activity compared to a control.

What Do Results Mean?

Results may indicate normal enzyme activity, reduced activity (suggesting a mitochondrial or metabolic disorder), or abnormal findings that warrant further testing or genetic counseling.

Common Conditions Monitored

SDH activity testing is often linked to conditions like Leigh syndrome, mitochondrial disorders, or certain genetic mutations affecting energy metabolism. It may also be part of diagnostic workups for unexplained neurological or muscular symptoms.

Reference range

Non-pregnant: <5 mIU/mLN/A

Specimen: whole-blood

No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

SDH Activity

Frequently asked questions

What preparation is needed?
No special preparation is typically required, but you may be asked to avoid certain medications or foods that could interfere with results. Follow your provider’s instructions.
How long does it take to get results?
Results are usually available within 1–3 business days, depending on lab processing times. Your provider will discuss findings with you during your follow-up visit.
Can this test be done at home?
No, this test requires a blood sample collected in a clinical setting by a healthcare professional. Home blood tests for enzyme activity are not standard.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy