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SDHD Gene Mutation Carrier Status (Blood)

Published: August 9, 2026Updated: August 16, 2026

This test checks whether you carry a mutation in the SDHD gene, which may increase your risk of certain cancers. It’s often done as part of genetic counseling or hereditary cancer testing.

Quick summary

["Knowing your SDHD mutation status can help guide cancer prevention and monitoring strategies."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
34511-6
Short code
SDHD gene Mut Anl Bld/T
Synonyms
SDHD gene Mut Anl Bld/T
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
molgen
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What This Test Measures

The SDHD gene helps regulate blood flow and cell growth. Mutations in this gene can raise the risk of hereditary diffuse gastric cancer (HDGC) and other cancers. This test identifies if you carry a specific mutation in your blood DNA.

Why It’s Done

Your doctor may recommend this test if you have a family history of certain cancers, such as stomach, thyroid, or colorectal cancers, or if you’re part of a genetic testing program for hereditary cancer syndromes.

Sample Collection

A small blood sample is taken from your arm. This sample is sent to a lab for genetic analysis to detect the SDHD mutation.

What to Expect Before the Test

There are no special preparations needed. You may feel slight discomfort from the needle, but it’s usually over quickly. If you’re pregnant or have a bleeding disorder, let your doctor know before the test.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

SDHD Gene Mutation Screening

Frequently asked questions

What Does a Positive or Negative Result Mean?
A positive result means you carry the SDHD mutation, which may raise your risk of certain cancers. A negative result means you do not carry this specific mutation, but other genetic tests may still be needed if family history suggests other risks.
Will This Test Show All Possible Mutations?
This test checks for the most common SDHD mutation linked to hereditary cancer risks. However, other mutations exist, and additional genetic testing may be recommended if needed.
Can I Get This Test Without a Doctor’s Referral?
Typically, this test is done through a healthcare provider’s order, often as part of a genetic counseling or hereditary cancer evaluation. Direct-to-consumer genetic testing may offer similar options but should be discussed with your doctor first.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy