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Serum Concentration of Secobarbital (Barbiturate Level)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of secobarbital, a barbiturate medication, in your blood. It helps assess drug levels, especially in cases of overdose or monitoring long-term therapy.

Quick summary

["This test helps doctors check if your medication dose is working properly or if you may need medical attention due to high levels."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
4424-8
Short code
Secobarbital Dose
Synonyms
Secobarbital Dose
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test if you’ve been prescribed secobarbital (a sedative/hypnotic) or if you’ve experienced symptoms like confusion, slow breathing, or unusual sleepiness. It’s also used in cases of suspected overdose or to monitor long-term use.

What Does the Test Measure?

The test detects the presence and concentration of secobarbital in your blood serum. This helps determine if your dose is therapeutic or if levels are dangerously high.

Sample Collection and Preparation

A blood sample is drawn from a vein in your arm. The blood is then processed to separate serum (the liquid part without clotting factors) for testing.

What Do Results Mean?

Results are reported as a concentration (e.g., micrograms per milliliter). High levels may indicate overdose, improper dosing, or drug interactions. Low levels may suggest insufficient medication. Always discuss results with your doctor.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Secobarbital is a potent central nervous system depressant. Elevated levels can impair breathing, cause coma, or lead to severe complications. Monitoring is critical for patients on long-term therapy or those with liver/kidney issues, as these organs metabolize and clear the drug. Misuse or improper dosing can be life-threatening.

Short name

Barbiturate Level (Serum)

Frequently asked questions

How often is this test typically ordered?
This test is usually ordered periodically during long-term use of secobarbital, especially if you’re taking other medications that interact with it. Your doctor may also order it if you experience symptoms like drowsiness, confusion, or breathing difficulties.
What symptoms might indicate abnormal results?
Symptoms that could correlate with abnormal secobarbital levels include extreme drowsiness, difficulty waking up, slow or shallow breathing, confusion, or loss of coordination. Seek emergency medical help if you or someone else shows these signs.
Can diet or other medications affect this test?
Yes, certain medications (e.g., other sedatives, antidepressants, or antibiotics) can interact with secobarbital and alter test results. Avoid drinking alcohol or taking other medications without consulting your doctor before your test.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy