Neutrophil count in cerebrospinal fluid (CSF) by automated cell differential

Why Is This Test Done?

Your healthcare provider may order this test if you have symptoms like severe headaches, neck stiffness, fever, confusion, or neurological issues. It’s often used to investigate conditions such as meningitis, encephalitis, or other infections or inflammatory processes in the central nervous system.

What Does the Result Mean?

A higher-than-normal neutrophil count in CSF may indicate an infection (e.g., bacterial meningitis), an inflammatory response, or other conditions affecting the brain or spinal cord. Lower-than-normal counts could suggest viral infections or other non-infectious processes. Results are interpreted by your doctor in the context of your symptoms and medical history.

Sample Collection and Preparation

A small amount of CSF is collected through a procedure called a lumbar puncture (spinal tap), where a needle is inserted into the spinal canal. The sample is then analyzed in a lab to count neutrophils and other cells.

What to Expect Before the Test

You may be asked to fast or avoid certain medications before the procedure, but this depends on your doctor’s instructions. You’ll likely be given instructions to empty your bladder beforehand. Avoid heavy lifting or strenuous activity for 24 hours before the test.