Epidermal growth factor receptor (EGFR) mutation status in plasma by targeted next-generation sequencing (NGS)
This test checks for specific genetic changes in a protein called EGFR that may be linked to certain types of lung cancer. These changes can help determine if a targeted cancer treatment might be effective for you.
["Helps guide personalized cancer treatment options based on genetic test results."]
Key facts at a glance
- LOINC
- 96310-8
- Short code
- S epidermidis DNA Bld Pos Ql NAA+non-prb
- Synonyms
- S epidermidis DNA Bld Pos Ql NAA+non-prb
- Category
- chemistry
- Sample
- whole-blood
- Container
- Lavender-top (EDTA)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- non-probe-amp-tar
- Specimen volume
- 3 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h
- Hemolysis max
- 0
- Lipemia max
- 0
- Icterus max
- 0
- TAT
- 4–24 hours
- Order
- routine
Why This Test Is Done
Your doctor may recommend this test if you have lung cancer and certain genetic markers suggest EGFR mutations. It’s also used in monitoring treatment response or assessing recurrence in patients with known EGFR-positive cancers.
What to Expect Before the Test
A simple blood draw is used to collect plasma. No special preparation is needed, but inform your doctor about any medications or supplements you’re taking, as they may affect results.
How the Test Works
Plasma is analyzed using advanced sequencing technology to detect small genetic changes in EGFR. These changes are compared against a reference database to identify mutations linked to cancer growth.
What the Results Mean
Positive results indicate the presence of EGFR mutations, which may influence treatment choices like targeted therapies or immunotherapy. Negative results mean no detectable mutations in this test.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Clinical significance: EGFR mutations are actionable targets in about 10–20% of lung cancer cases, particularly in non-small cell lung cancer (NSCLC). These mutations can help tailor treatment to slow or stop cancer progression, but results must be interpreted alongside clinical factors and other genetic tests.
Short name
EGFR Mutation Test (Plasma)
Frequently asked questions
What does a positive result mean for my treatment options?
How long will it take to get my results?
Can I stop taking medications before this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy