Skip to content

Epidermal Dermal Fibroblast DNA Integrity by Probe (Nucleic Acid Analysis)

Published: August 9, 2026Updated: August 16, 2026

This test assesses the genetic material (DNA) in skin cells for structural integrity, which may help detect signs of cellular stress, aging, or potential genetic abnormalities in the skin layer.

Quick summary

["This test may support understanding skin health or underlying conditions affecting cell function."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
92776-4
Short code
S epidermidis DNA Bld Pos Ql NAA+probe
Synonyms
S epidermidis DNA Bld Pos Ql NAA+probe
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What This Test Measures

The test analyzes DNA extracted from epidermal and dermal fibroblasts (skin cells) using a specialized probe. It evaluates the structural integrity of the DNA, which can be influenced by factors like aging, exposure to environmental stressors, or certain medical conditions. This is not a routine blood test but may be used in specialized research or diagnostic contexts for skin-related studies.

Why It Might Be Ordered

This test could be part of advanced research, specialized diagnostics, or monitoring for conditions affecting skin cell health. It may also be used in studies assessing genetic stability in skin tissues, though it is not a standard clinical test for most routine medical evaluations.

How the Test Works

The test involves collecting a sample of skin cells (fibroblasts) from the epidermis and dermis. The DNA is then isolated and analyzed using a probe to detect any disruptions or abnormalities in its structure. This process helps determine the overall integrity of the genetic material.

What the Results Mean

Results may indicate normal DNA integrity or suggest potential issues such as oxidative stress, DNA damage, or genetic instability in skin cells. Interpretation depends on clinical context and may require input from a healthcare provider or researcher specializing in skin biology.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

DNA Integrity Test (Skin Fibroblast)

Frequently asked questions

What could cause this test to be ordered?
This test is not routinely performed for general health checks. It may be ordered in specialized research settings, for advanced skin-related diagnostics, or in cases where skin cell integrity is suspected to be compromised due to conditions like severe dermatitis, genetic disorders affecting skin, or exposure to harmful substances.
What are the possible implications of abnormal results?
Abnormal results might suggest underlying cellular stress, DNA damage, or genetic abnormalities in skin cells. This could be linked to aging, chronic skin conditions, or exposure to environmental toxins. Further evaluation by a healthcare provider would be needed to determine next steps, as this test is not a standalone diagnostic tool for most conditions.
How often is this test performed?
This test is not a standard part of regular medical testing and is typically reserved for specialized research studies, advanced diagnostics, or specific clinical investigations involving skin cell biology. It is not performed routinely for general health monitoring.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy