Serum or Plasma Immunoassay for Septin-5 IgG Antibody (Screening)
This test measures antibodies to septin-5, a protein that may play a role in certain autoimmune conditions. It is often used as part of screening for systemic lupus erythematosus (SLE) or other related disorders.
["This screening test helps identify potential autoimmune activity in your blood."]
Key facts at a glance
- LOINC
- 109748-4
- Short code
- Septin-5 IgG Msmt CSF
- Synonyms
- Septin-5 IgG Msmt CSF
- Category
- coagulation
- Sample
- csf
- Container
- Sterile tube
- Units
- N/A
- Ref low
- 0.8
- Ref high
- 1.2
- Critical range
- — – 5 N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- CPT
- 85610
- SNOMED
- 396252006
- Specimen volume
- 1-2 mL
- Stability
- Immediate analysis required, Refrigerated: 1h
- Hemolysis max
- 200
- TAT
- 4–24 hours
- Order
- routine
Why This Test Might Be Ordered
Your healthcare provider may recommend this test if you have symptoms or risk factors for autoimmune diseases, such as joint pain, fatigue, rash, or a history of similar conditions like lupus or rheumatoid arthritis. It may also be used in follow-up testing if you’ve had other autoimmune-related blood tests.
What to Expect Before the Test
No special preparation is needed. You’ll provide a blood sample (serum or plasma) by venipuncture, similar to other routine blood tests. If you’re taking blood thinners, let your provider know before the test.
What the Test Results Mean
This test is a screening tool, meaning it may detect antibodies in your blood but does not confirm a specific diagnosis. Positive results should be followed up with additional testing, such as confirmation assays or clinical correlation with symptoms.
Common Conditions Linked to Septin-5 Antibodies
Septin-5 antibodies are sometimes associated with systemic lupus erythematosus (SLE) or other autoimmune conditions, though they are not diagnostic on their own. They may appear in people with active inflammation or immune system dysregulation.
Reference range
INR: 0.8-1.2 (warfarin: 2.0-3.0)N/A
Inform your healthcare provider if you are taking blood thinners. No special preparation required.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
◆Associated findings1
Short name
Septin-5 IgG Antibody (Screen)
Frequently asked questions
What does a positive result mean?
Can this test be used to diagnose lupus or another autoimmune disease?
How often should I get this test if I have symptoms?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy