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Serum Ammonia Concentration

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of ammonia, a waste product, in your blood serum. Ammonia is produced when proteins break down in your body.

Quick summary

["Ammonia levels can help diagnose liver or kidney issues or monitor certain medical conditions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
27223-7
Short code
Serine Amn-sCnc
Synonyms
Serine Amn-sCnc
Category
chemistry
Sample
fluid
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
2-5 mL
Stability
Room temperature: 2h, Refrigerated: 24h
Hemolysis max
300
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order a serum ammonia test if you have symptoms like confusion, fatigue, or trouble breathing. It’s also used to check for liver disease, kidney problems, or metabolic disorders. Sometimes, it’s done before or after surgery, especially if you have a history of liver or kidney issues.

What to Expect Before the Test

You’ll likely have a small needle inserted into your arm or vein to draw blood. The process is quick and usually painless. Avoid eating or drinking for a few hours before the test if your provider recommends it, as food can affect ammonia levels.

What the Results Mean

High ammonia levels may indicate problems with your liver or kidneys, which can’t properly remove waste from your blood. Low levels might suggest certain metabolic disorders or overmedication with drugs that lower ammonia. Your provider will discuss these results with you in detail.

Common Conditions Monitored

This test is often used to monitor liver diseases (like cirrhosis), kidney failure, or conditions affecting how your body processes proteins. It can also help track how well treatments for these conditions are working.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Serum Ammonia

Frequently asked questions

What causes high ammonia levels?
High ammonia levels can be caused by liver disease (such as cirrhosis), kidney problems, certain metabolic disorders, or conditions that slow down how your body breaks down proteins. It can also occur in people with severe dehydration or those on certain medications.
What causes low ammonia levels?
Low ammonia levels are less common and may be linked to overmedication with drugs that reduce ammonia, certain genetic disorders, or severe infections that affect protein metabolism. Rarely, it can occur in people with very low protein intake.
How often should this test be done?
The frequency depends on your health condition. If you have a chronic liver or kidney disease, your provider may order this test regularly to monitor your condition. If you’re undergoing treatment, they may check it more often to adjust care.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy