Serine and Creatinine, Urine
Measures serine and creatinine in urine to help evaluate amino acid excretion while accounting for differences in urine concentration.
["This test can help identify abnormal urinary serine excretion and guide evaluation for metabolic or inherited conditions."]
Key facts at a glance
- LOINC
- 13808-1
- Short code
- Serine/Creat Ur
- Synonyms
- Serine/Creat Ur
- Category
- kidney
- Sample
- urine
- Container
- Sterile urine container
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Specimen volume
- 10 mL
- Stability
- Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 0
- Lipemia max
- 0
- Icterus max
- 0
- TAT
- 4–24 hours
- Order
- routine
What is this test?
This test measures the amino acid serine and the waste product creatinine in a urine sample. Creatinine helps show how concentrated the urine is, which allows the amount of serine being lost in the urine to be interpreted more accurately.
Why might I need this test?
A clinician may order this test when symptoms suggest an amino acid metabolism disorder, nutritional problem, or another condition that may affect urinary amino acid excretion. It may also be used to monitor treatment for certain inherited metabolic diseases.
How is the test performed?
A urine sample is analyzed in the laboratory to determine the amount of serine and creatinine present. The results may be reported individually or together as a ratio, depending on the laboratory.
How do I prepare for the test?
Follow the collection instructions provided by your healthcare professional, including whether a random or timed urine collection is required. Tell the laboratory if you are taking supplements, medications, or receiving intravenous nutrition, because these can affect the results.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
An elevated amount of serine in urine may indicate increased loss of this amino acid and can occur with certain inherited metabolic disorders, kidney-related effects, or medication-related changes. Low urinary serine may be influenced by low protein intake, illness, or treatment and is not usually interpreted by itself.
Creatinine varies with urine concentration and muscle production, so abnormal serine results should be interpreted with the creatinine measurement, clinical findings, and other laboratory tests. A qualified healthcare professional can explain what the results mean for you.
Short name
Urine serine and creatinine
Frequently asked questions
What does the urine serine test measure?
Why are serine and creatinine measured together?
Does an abnormal result confirm a genetic disorder?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy