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Serological screening for antibodies to infectious agents in maternal blood during pregnancy

Published: August 9, 2026Updated: August 17, 2026

This test checks for antibodies in your blood that may indicate exposure to certain infections, helping ensure your baby’s safety during pregnancy.

Quick summary

["A simple blood test to screen for potential infections that could affect your pregnancy."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
85717-7
Short code
Serologic tx pre pregnancy Mother
Synonyms
Serologic tx pre pregnancy Mother
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Critical range
0.5 N/A – —
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may recommend this test if you’re pregnant or planning to become pregnant. It helps identify whether you’ve been exposed to infections like rubella, toxoplasmosis, or others that could pose risks to your baby’s health. Early detection allows for appropriate precautions or treatment if needed.

What to Expect During the Test

A small blood sample is taken from your arm, usually in a clinic or doctor’s office. The process is quick and typically painless. You may feel a slight pinch, but it doesn’t usually cause discomfort. No special preparation is needed.

How the Results Are Used

The results help determine if you have protective antibodies against certain infections. If antibodies are found, it suggests you’ve already been exposed and are likely immune. If not, further testing or vaccination may be recommended to protect your baby.

Common Infections Screened For

This test may screen for antibodies to infections such as rubella (German measles), toxoplasmosis (a parasite), cytomegalovirus (CMV), and others. The specific infections included depend on local guidelines and your healthcare provider’s recommendations.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Pregnancy serology screen

Frequently asked questions

What does a positive or negative result mean?
A positive result for antibodies indicates you have likely been exposed to the infection in the past and your body has produced protective antibodies. This is generally safe for your pregnancy. A negative result means you may not have these antibodies, and further evaluation or vaccination may be advised to prevent potential risks to your baby.
How often should I get this test?
This test is typically done once during pregnancy, usually in the first or second trimester, depending on your healthcare provider’s protocol. Some providers may recommend it earlier if you have risk factors or specific concerns.
Can I eat or drink before this test?
No special preparation is needed. You can eat and drink normally before the blood draw. However, always follow your healthcare provider’s instructions for any specific guidelines they may provide.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy