Serological test for syphilis antibodies in serum (pre-pregnancy maternal screening)
This test checks for syphilis antibodies in your blood to help determine if you have been exposed to the bacteria that cause syphilis. It’s often used during pregnancy to ensure your health and your baby’s health are protected.
["A simple blood test to screen for syphilis, a serious but treatable infection that can affect both you and your baby if not detected early."]
Key facts at a glance
- LOINC
- 85675-7
- Short code
- Serologic tx result pre pregnancy Mother
- Synonyms
- Serologic tx result pre pregnancy Mother
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Critical range
- 0.5 N/A – —
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why This Test Matters During Pregnancy
Syphilis can cause serious complications if left untreated, including miscarriage, stillbirth, or severe health issues for your baby. Early detection allows for prompt treatment with antibiotics, which can prevent these risks. This test is part of routine prenatal care to keep you and your baby safe.
What to Expect Before the Test
You’ll likely have a small needle inserted into your arm to draw blood. The process is quick and usually causes only minor discomfort. No special preparation is needed, but let your healthcare provider know if you’re on any medications or have allergies.
What the Test Results Mean
If your test is positive, it means your body has detected syphilis antibodies, indicating past or current infection. Your healthcare provider will discuss next steps, which may include additional testing or treatment. A negative result means no detectable antibodies, but it doesn’t guarantee you’re completely free of syphilis—re-testing may be recommended if symptoms or risk factors persist.
What Happens If You Get a Positive Result?
If you test positive, your healthcare provider will work with you to confirm the diagnosis and determine the best treatment plan. Syphilis is highly treatable with antibiotics, and early treatment can prevent serious complications. You may need follow-up tests to monitor your response to treatment.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Syphilis can cross the placenta and affect fetal development, leading to congenital syphilis—a condition that can cause birth defects, developmental delays, or even stillbirth. Early detection through screening during pregnancy is critical. If syphilis is diagnosed, treatment can be started immediately to minimize risks to both mother and baby. This test helps ensure you receive timely care if needed, supporting a healthy pregnancy.
Short name
Syphilis Antibody Screen (Serum)
Frequently asked questions
How often should I get this test if I’m not pregnant?
What are the symptoms of syphilis if I have it?
Can I get syphilis from oral sex?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy