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Serine Protease Inhibitor 1 (SERPINC1) Gene Mutation Test via Whole Blood DNA

Published: August 9, 2026Updated: August 16, 2026

This test checks for genetic changes in the SERPINC1 gene, which may be linked to certain blood disorders or conditions affecting protein function in your body.

Quick summary

["It helps identify if you carry mutations that could influence your risk for inherited blood or protein-related health concerns."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
70107-8
Short code
SERPINC1 gene Mut Tested Bld/T
Synonyms
SERPINC1 gene Mut Tested Bld/T
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
molgen
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have a family history of conditions like alpha-1 antitrypsin deficiency (a genetic disorder affecting lung and liver function) or unexplained blood abnormalities. It could also be part of genetic counseling for certain inherited diseases.

What to Expect Before the Test

You’ll provide a small blood sample, usually drawn from your arm. No special preparation is needed, but inform your provider about any medications or supplements you’re taking.

How the Test Works

The test analyzes your whole blood DNA to detect specific mutations in the SERPINC1 gene. Results help determine if you have inherited variants that may affect protein production or function.

What the Results Mean

Results may show normal variants, known disease-causing mutations, or variants of uncertain significance. Your provider will discuss findings in the context of your medical history and family health.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

SERPINC1 Mutation Test

Frequently asked questions

What does a positive result mean?
A positive result indicates you may carry mutations linked to alpha-1 antitrypsin deficiency or other related conditions. Your provider will explain how this might affect your health and next steps.
How soon will I get my results?
Results typically take 2–4 weeks. Your healthcare provider will contact you directly with findings and next steps, including follow-up testing or referrals if needed.
Can I have my results explained in plain language?
Yes, your provider will discuss results in detail, including what they mean for your health. If you have questions, ask for clarification during your follow-up visit.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy