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Serine Protease Inhibitor 1 Gene Mutation Status (Blood)

Published: August 9, 2026Updated: August 16, 2026

This test checks whether you carry a mutation in the gene that produces serine protease inhibitor 1, a protein that helps regulate blood clotting and other processes in your body.

Quick summary

["Understanding your genetic mutation status may help guide treatment or monitoring for conditions linked to this gene."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
48028-5
Short code
SERPINE1 gene Mut Anl Bld/T
Synonyms
SERPINE1 gene Mut Anl Bld/T
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
molgen
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have a family history of bleeding disorders, clotting issues, or conditions like hereditary angioedema. It could also be used for genetic counseling or preconception screening.

What to Expect Before the Test

No special preparation is needed. A blood sample will be taken from a vein in your arm, similar to other routine blood tests. You may feel slight discomfort, but it usually lasts only a few minutes.

What the Test Results Mean

Results will indicate whether you have the mutation in the serine protease inhibitor 1 gene. This information can help identify risks for specific health conditions and inform personalized care plans.

Common Conditions Linked to This Mutation

Mutations in this gene may be associated with conditions affecting blood clotting, inflammation, or other systemic processes. Your provider will discuss how these findings may apply to your health.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Genetic Testing for Serine Protease Inhibitor 1

Short name

Serine Protease Inhibitor 1 Mutation Test

Frequently asked questions

What does a positive or negative result mean for my health?
A positive result means you carry the mutation in the serine protease inhibitor 1 gene. This may increase your risk for certain conditions, such as bleeding disorders or hereditary angioedema, depending on other factors. Your healthcare provider will assess your risk and recommend next steps, which may include monitoring, lifestyle adjustments, or preventive treatments. A negative result means you do not carry this specific mutation but does not rule out other genetic variations.
How often should I get this test?
Genetic testing like this is typically done once unless there’s a change in your health status, family history, or medical advice from your provider. If you have a family member with a known mutation, your provider may recommend monitoring or testing at specific intervals.
Can lifestyle changes affect this test result?
This test checks your genetic makeup, which is stable and does not change due to lifestyle factors like diet or exercise. However, conditions linked to this mutation (e.g., bleeding episodes) may be influenced by lifestyle choices, and your provider may advise modifications to manage symptoms.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy