Skip to content

Serum/plasma concentration of sertraline (antidepressant medication)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of sertraline, a medication used to treat depression, anxiety, and other mental health conditions, in your blood.

Quick summary

["Understanding your sertraline blood levels helps your doctor monitor your dose and ensure it’s working safely for you."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
73154-7
Short code
Sertraline ind plt IgM SerPl Ql FC
Synonyms
Sertraline ind plt IgM SerPl Ql FC
Category
hematology
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
flow-cytometry
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your doctor may order this test if you’re taking sertraline long-term to check if your dose is appropriate. It can also help detect if your body is processing the medication differently than expected, which might affect your symptoms or side effects.

What to Expect Before the Test

No special preparation is needed. You’ll provide a blood sample, usually drawn from a vein in your arm. If you’re on a blood thinner, let your doctor know before the test.

What the Test Results Mean

Results show your current sertraline concentration. While reference ranges vary by lab, they help guide whether your dose is therapeutic (effective) or potentially too high/low. Your doctor will interpret these results in the context of your symptoms and treatment plan.

Possible Reasons for Testing

Common reasons include evaluating treatment response, adjusting medication doses, or investigating symptoms like dizziness, nausea, or unusual fatigue that may relate to sertraline levels.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Sertraline levels help prevent toxicity (e.g., from accidental overdose) or subtherapeutic doses (e.g., if symptoms persist despite treatment). Abnormally high levels may require dose reduction or monitoring for side effects, while low levels may prompt dose increases. Always discuss results with your healthcare provider.

Short name

Sertraline Level

Frequently asked questions

How often should I get this test?
Your doctor will determine the timing based on your treatment plan. Typically, initial tests are done shortly after starting sertraline, then periodically as needed (e.g., every few months). Follow-up depends on your symptoms and how your body responds to the medication.
What does a ‘therapeutic’ level mean?
A ‘therapeutic’ level isn’t a single number but a range that balances effectiveness and safety. Your doctor will use your specific results, symptoms, and medical history to decide if your dose is working well for you. It’s not a one-size-fits-all target.
Can I eat or drink before this test?
You can eat and drink normally unless instructed otherwise. Some tests may require fasting, but this test does not. Always check with your lab or doctor for any specific instructions.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy