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Serum or Plasma Concentration of Sertraline (Sertraline Level)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of sertraline, a medication used to treat depression, anxiety, and other mental health conditions, in your blood.

Quick summary

["Knowing your sertraline level helps your doctor monitor your dose and ensure it’s working safely for you."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
72956-6
Short code
Sertraline (neut) IgG SerPl Ql FC
Synonyms
Sertraline (neut) IgG SerPl Ql FC
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
flow-cytometry
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Matters

Sertraline is a selective serotonin reuptake inhibitor (SSRI) that affects brain chemicals. Your body processes it over time, so levels can change. This test helps doctors check if your dose is appropriate and if you’re experiencing side effects.

What to Expect Before the Test

No special preparation is needed. You’ll provide a blood sample, usually drawn from a vein in your arm. If you’re on other medications, tell your doctor or lab technician beforehand.

How the Results Are Used

Results help your doctor adjust your dose if needed—too little may not work, while too much could cause side effects like nausea or dizziness. They may also check levels if you’re taking other medications that interact with sertraline.

Possible Results and Next Steps

Your results will be compared to a general reference range for sertraline in blood. If levels are too high or too low, your doctor may change your dose or recommend further monitoring.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Monitoring Medication Effectiveness and Safety

Short name

Sertraline Level

Frequently asked questions

How often should I get this test?
Your doctor will determine the timing based on your treatment plan. Typically, they may check levels after starting sertraline, during dose adjustments, or if you experience unusual symptoms.
What does a low sertraline level mean?
A low level might indicate your dose isn’t providing enough of the medication to help your symptoms. Your doctor may increase it or switch to a different approach.
Can I eat or drink before this test?
You can eat and drink normally unless instructed otherwise. Avoid caffeine or alcohol before the blood draw, as they may affect test results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy