Skip to content

Sezary Cell Count in Blood (Manual Count)

Published: August 9, 2026Updated: August 16, 2026

This test measures the number of Sezary cells, a type of abnormal white blood cell often found in people with a rare blood disorder called Sezary syndrome, which is part of cutaneous T-cell lymphoma.

Quick summary

["Sezary cells may indicate a serious blood cancer requiring further medical evaluation."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
33857-4
Short code
Sezary Cells NFr Bld Manual
Synonyms
Sezary Cells NFr Bld Manual
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
manual-count
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your doctor may order this test if you have symptoms like persistent itching, rash, or unexplained weight loss, or if they suspect a blood-related condition like Sezary syndrome. It helps determine if abnormal cells are present in your bloodstream.

What Does a High or Low Count Mean?

A high count of Sezary cells is strongly linked to Sezary syndrome. While a normal count suggests no significant presence of these cells, a very low count might not rule out the condition if other symptoms persist.

How Is the Test Performed?

A blood sample is taken from a vein, usually in your arm. The sample is then examined under a microscope by a trained technician to count the Sezary cells manually.

What Are the Next Steps?

If Sezary cells are found, your doctor will likely recommend further testing, such as a biopsy or additional blood work, to confirm the diagnosis and guide treatment options.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Sezary cells are a hallmark of Sezary syndrome, a type of advanced cutaneous T-cell lymphoma. Their presence can indicate disease progression and may influence treatment decisions, including chemotherapy, radiation, or targeted therapies.

Short name

Sezary Cells in Blood

Frequently asked questions

What does a positive result mean for my health?
A positive result (detecting Sezary cells) suggests a high likelihood of Sezary syndrome or related blood disorders. This finding will prompt further medical evaluation to confirm diagnosis and develop a treatment plan.
How long does it take to get results from this test?
Results from this manual count test are typically available within a few days, depending on lab processing times. Follow-up with your healthcare provider for interpretation.
Can lifestyle changes affect Sezary cell counts?
While lifestyle factors like diet and stress may influence overall health, they generally do not directly affect Sezary cell counts in this test. Your doctor will focus on medical interventions for managing the condition.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy