Serum/Plasma Immunoassay for Anti-Drug Antibody (Probe) to a Specific Protein Target
This test checks for antibodies your body may produce against a medication or treatment you’re receiving. These antibodies can affect how well your medicine works or cause side effects.
["Anti-drug antibodies may alter treatment effectiveness or trigger unexpected reactions."]
Key facts at a glance
- LOINC
- 105680-3
- Short code
- S. gordonii DNA Spec Ql NAA+probe
- Synonyms
- S. gordonii DNA Spec Ql NAA+probe
- Category
- coagulation
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- probe-amp-tar
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why This Test Is Done
Your healthcare provider may order this test if you’re receiving a medication that’s known to sometimes trigger an immune response. It helps monitor whether your body is developing antibodies against the drug, which could impact your treatment plan.
What to Expect Before the Test
No special preparation is needed. You’ll likely have a small needle inserted into your arm or vein to draw blood. If you’re on a long-term medication, your provider may discuss how this test fits into your ongoing care.
How the Test Works
A small sample of your blood (serum or plasma) is taken and tested using an immunoassay method. This detects the presence of antibodies that bind to the specific protein target of your medication, helping identify if an immune response has occurred.
Possible Results and Next Steps
If antibodies are found, your provider will review your symptoms, medication history, and test results to determine if adjustments to your treatment are needed. Positive results don’t always mean you’ll stop the medication, but they may guide closer monitoring.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Anti-drug antibodies can interfere with how well a medication works by binding to it in your body. This can lead to reduced effectiveness, increased side effects, or require dose adjustments. Some medications are more prone to triggering these antibodies, so testing is especially important for patients on biologics, monoclonal antibodies, or other targeted therapies.
Short name
Anti-drug antibody screening
Frequently asked questions
What does a positive result mean?
Can I stop taking my medication if I have antibodies?
How often will I need this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy