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Serum Sex Hormone-Binding Globulin (SHBG) Concentration

Published: August 9, 2026Updated: August 17, 2026

This test measures the amount of SHBG, a protein in your blood that helps transport sex hormones like estrogen and testosterone.

Quick summary

["SHBG levels can reflect hormone balance and may indicate conditions affecting hormone metabolism."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
65359-2
Short code
SHBG pre/p chal SerPl-sCnc
Synonyms
SHBG pre/p chal SerPl-sCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
10
Ref high
50
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
84270
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may check SHBG levels if you have symptoms related to hormone imbalances, such as irregular menstrual cycles, low libido, or signs of hormonal disorders. It can also be used in research or specialized evaluations for conditions like polycystic ovary syndrome (PCOS) or hormone-related cancers.

What to Expect Before the Test

No special preparation is needed, but you may be asked to fast for 8–12 hours before the draw if your lab requires it. Wear a comfortable shirt for easy access to your arm.

How the Test Works

A small blood sample is taken from a vein in your arm. The blood is sent to a lab where it is analyzed using a specialized immunoassay method to measure SHBG concentration.

What the Results Mean

Results are compared to a general reference range for healthy adults, but individual results can vary based on age, sex, and health status. Low levels may suggest conditions like liver disease or genetic disorders, while high levels could relate to thyroid issues or certain medications.

Reference range

NCBI: SHBG Male 10-50 nmol/L; Female 20-90 nmol/LN/A

Specimen: serum

No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

SHBG Level

Frequently asked questions

What might cause abnormal results?
Abnormal SHBG levels can be influenced by factors like liver disease, thyroid disorders, kidney problems, or certain medications (e.g., anticonvulsants). Genetic conditions or hormonal imbalances may also affect SHBG production or function.
How often should this test be repeated?
If your results are outside the reference range, your provider may recommend retesting after addressing potential underlying causes, such as adjusting medications or treating a condition like liver disease.
Can lifestyle changes affect SHBG levels?
Yes, factors like diet (especially high-fat or high-protein diets), weight changes, and certain supplements (e.g., soy, phytoestrogens) may influence SHBG levels. Discuss these with your provider if you’re making significant lifestyle adjustments.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy