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Serum Sex Hormone-Binding Globulin (SHBG) Concentration

Published: August 9, 2026Updated: August 17, 2026

This test measures the amount of SHBG, a protein in your blood that helps transport sex hormones like estrogen and testosterone.

Quick summary

["SHBG levels can reflect hormone balance and may be checked for conditions like infertility, hormone disorders, or metabolic health."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
2942-1
Short code
SHBG SerPl-mCnc
Synonyms
SHBG SerPl-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
10
Ref high
50
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
84270
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What SHBG Measures

SHBG binds to sex hormones in your bloodstream, helping regulate their availability. This test quantifies its concentration in your serum, which can indicate how effectively your body is processing these hormones.

Why It’s Ordered

Your healthcare provider may order this test if you have symptoms or conditions related to hormone imbalances, such as irregular menstrual cycles, low libido, or signs of metabolic syndrome.

How It’s Performed

A blood sample is drawn from a vein, typically in your arm. The serum portion is then analyzed using an immunoassay method to measure SHBG levels accurately.

What to Expect Before the Test

No special preparation is usually needed, but you may be asked to fast for 8–12 hours before the test if your provider specifies it. Wear comfortable clothing and plan to stay for about 15 minutes while the blood is drawn.

Reference range

NCBI: SHBG Male 10-50 nmol/L; Female 20-90 nmol/LN/A

Specimen: serum

No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

SHBG levels can provide clues about hormonal health, including potential issues with estrogen or testosterone metabolism. Low levels may be linked to conditions like polycystic ovary syndrome (PCOS) or metabolic disorders, while high levels could suggest liver disease or certain genetic factors.

Short name

SHBG Level

Frequently asked questions

What does an abnormal SHBG level mean?
An abnormal result doesn’t diagnose a specific condition alone, but it may prompt further testing or discussions with your provider about hormone balance, metabolic health, or other underlying factors.
How long will results take?
Results are typically available within 1–3 business days, depending on your lab’s processing time. Your provider will discuss them with you during your follow-up visit.
Can diet or medications affect SHBG levels?
Yes, certain foods, vitamins, and medications—such as those for diabetes, thyroid disorders, or hormonal treatments—can influence SHBG levels. Always inform your provider about all medications or supplements you’re taking.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy