Skip to content

Serum Sex Hormone-Binding Globulin (SHBG) Concentration

Published: August 9, 2026Updated: August 17, 2026

This test measures the amount of SHBG, a protein in your blood that helps transport certain hormones, including estrogen and testosterone.

Quick summary

["SHBG levels can give clues about hormone balance and potential health risks."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
13967-5
Short code
SHBG SerPl-sCnc
Synonyms
SHBG SerPl-sCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
10
Ref high
50
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
84270
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your doctor may request this test if you have symptoms related to hormone imbalances, such as irregular menstrual cycles, low libido, or signs of metabolic syndrome. It may also be used to monitor conditions like polycystic ovary syndrome (PCOS) or to assess liver function indirectly, as SHBG production is influenced by liver health.

What to Expect Before the Test

No special preparation is usually needed. You may fast for 8–12 hours before the test if instructed, but this is not always required. Bring any medications you’re taking, as they could affect results.

How the Test Works

A blood sample is drawn from a vein, typically in your arm. The sample is sent to a lab where SHBG levels are measured using an immunoassay method to detect and quantify the protein.

What the Results Mean

Results are reported as a concentration (typically in nmol/L or µg/dL). While reference ranges vary by lab, higher or lower levels than expected may signal conditions like hormone disorders, liver disease, or genetic variations.

Reference range

NCBI: SHBG Male 10-50 nmol/L; Female 20-90 nmol/LN/A

Specimen: serum

No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

SHBG Level

Frequently asked questions

What causes SHBG levels to change?
SHBG levels can be influenced by factors like age, diet, medications (e.g., birth control, anticonvulsants), liver disease, thyroid conditions, and obesity. Hormonal changes, such as pregnancy or menopause, may also affect results.
Can diet or exercise affect SHBG levels?
Yes, diet and exercise can play a role. High-fat or high-sugar diets may lower SHBG, while weight loss or increased physical activity might raise it. Certain foods, like soy or flaxseed, may also have indirect effects.
Do I need to take anything special before this test?
Most tests don’t require special prep, but follow your doctor’s instructions. If fasting is recommended, avoid eating or drinking anything except water for 8–12 hours before drawing blood.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy