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Serum or Plasma Alpha-1 Antitrypsin (A1AT) Concentration

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of Alpha-1 Antitrypsin, a protein produced by the liver that helps protect the lungs from damage caused by enzymes released during inflammation.

Quick summary

["Alpha-1 Antitrypsin helps prevent lung disease and supports immune function; low levels may indicate genetic disorders or liver issues."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
7699-2
Short code
Sheep Sorrel BasoBnd Ab Qn
Synonyms
Sheep Sorrel BasoBnd Ab Qn
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
lhr
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test to check for conditions like Alpha-1 Antitrypsin deficiency, which can lead to chronic lung diseases (such as emphysema) or liver problems. It may also be used to monitor liver function or evaluate symptoms like persistent coughing, wheezing, or unexplained fatigue.

What to Expect Before the Test

No special preparation is needed. You may have blood drawn from a vein in your arm, usually while lying down. If you’re taking blood thinner medications, inform your provider beforehand to avoid unusual bleeding.

What the Test Results Mean

Results are compared to a general reference range for healthy adults. Very low levels may suggest genetic deficiency, while very high levels could indicate liver disease or other conditions. Your provider will interpret results in the context of your overall health.

Common Conditions Linked to Results

Low Alpha-1 Antitrypsin levels are strongly linked to Alpha-1 Antitrypsin deficiency, which can cause lung diseases (e.g., chronic obstructive pulmonary disease) or liver cirrhosis. High levels may be associated with acute liver inflammation or other metabolic conditions.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Alpha-1 Antitrypsin Level

Frequently asked questions

What causes my Alpha-1 Antitrypsin level to be low?
Low levels are often due to a genetic mutation passed from parents. Other rare causes may include chronic liver disease or certain medications. If you have a family history of lung or liver disease, this test can help confirm a diagnosis.
How often should I get this test?
If you have a confirmed Alpha-1 Antitrypsin deficiency, your provider may recommend regular monitoring to track lung or liver function. For routine screening, results are typically checked only if symptoms or risk factors (like smoking) suggest a need.
Can diet or supplements affect this test?
Dietary changes alone won’t alter Alpha-1 Antitrypsin levels, but certain medications (e.g., some liver-protective drugs) may influence results. Always discuss supplements or new medications with your provider before testing.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy