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D-dimer (Plasma) – Quantitative Measurement

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of D-dimer, a breakdown product of a blood-clotting protein, to help assess whether you may have had a clot that has since dissolved.

Quick summary

["D-dimer helps rule out blood clots or help guide treatment decisions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
55398-2
Short code
Short Fibrin D-dimer FEU & DDU Pnl PPP
Synonyms
Short Fibrin D-dimer FEU & DDU Pnl PPP
Category
coagulation
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
86430
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is D-Dimer Used For?

D-dimer is primarily used to evaluate the risk of blood clots (thrombosis) or disseminated intravascular coagulation (DIC), a rare but serious condition where clots form throughout the body. It can also assist in diagnosing conditions like pulmonary embolism (blockage in the lungs) or deep vein thrombosis (clot in a vein).

How Is the Test Performed?

A small blood sample is drawn from a vein, usually in your arm. The blood is processed to separate plasma, where the D-dimer levels are measured using a sensitive immunoassay technique.

What Does a High or Low Level Mean?

Elevated D-dimer levels often suggest recent clot formation or breakdown, which may indicate conditions like a pulmonary embolism or deep vein thrombosis. However, false positives can occur due to pregnancy, surgery, or other inflammatory conditions. Low or normal levels generally mean there is less likelihood of active clotting, but they don’t rule out all clot-related issues entirely.

When Might You Need This Test?

Your healthcare provider may order a D-dimer test if you have symptoms like shortness of breath, chest pain, leg swelling, or if you’ve had recent surgery, trauma, or a history of blood clots.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

D-dimer plays a key role in diagnosing and managing conditions involving abnormal blood clotting or clot breakdown. It helps narrow down potential causes and supports treatment decisions, such as anticoagulant therapy for blood clots.

Short name

D-Dimer

Frequently asked questions

Why might my D-dimer test result be higher than expected?
Several factors can cause elevated D-dimer levels, including recent surgery or trauma, pregnancy, infections, or inflammatory conditions. Your healthcare provider will consider your medical history and symptoms when interpreting the result.
Can a low D-dimer level mean I don’t have a blood clot?
A low or normal D-dimer level reduces the likelihood of recent clot formation but doesn’t definitively rule out all blood clots. Other tests and clinical evaluation are often needed for a full assessment.
How long does it take to get my D-dimer test results?
Results are typically available within a few hours to a couple of days, depending on your lab’s processing times. Your healthcare provider will discuss the results with you during your follow-up visit.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy