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Sialooligosaccharides/Creatinine Ratio, Urine

Published: August 9, 2026Updated: August 16, 2026

A urine test that measures sialooligosaccharides relative to creatinine. It can support evaluation for inherited glycoprotein metabolism disorders, including alpha-mannosidosis.

Quick summary

["An elevated urine sialooligosaccharide-to-creatinine ratio may indicate a lysosomal storage or glycoprotein metabolism disorder."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
34526-4
Short code
Sialooligosacch/Creat Ur-Rto
Synonyms
Sialooligosacch/Creat Ur-Rto
Category
kidney
Sample
urine
Container
Sterile urine container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What is this test?

This test measures sialooligosaccharides, a group of small sugar-containing molecules, in your urine. The result is adjusted using your urine creatinine level so that the measurement is less affected by how concentrated or dilute the urine is.

Why might I need this test?

The test may be used when symptoms suggest an inherited disorder of glycoprotein or lysosomal metabolism, particularly alpha-mannosidosis. It is usually interpreted alongside medical history, physical findings, and other laboratory tests.

How is the test performed?

A urine specimen is collected and analyzed in the laboratory for sialooligosaccharides and creatinine. The laboratory then calculates the sialooligosaccharide-to-creatinine ratio.

How do I prepare for the test?

Follow the urine collection instructions provided by the laboratory or your clinician. Fasting is generally not required, and you may be asked to provide a clean-catch urine sample.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Urine sialooligosaccharide ratio

Frequently asked questions

What does this urine test measure?
It measures sialooligosaccharides relative to creatinine in the urine. Sialooligosaccharides are small sugar-containing molecules that can accumulate in certain inherited metabolic disorders.
Why is the result divided by creatinine?
Urine creatinine helps account for differences in urine concentration. Using the ratio makes results more comparable between samples and across changes in fluid intake.
Does an abnormal result diagnose alpha-mannosidosis?
No. An elevated ratio can support further evaluation for alpha-mannosidosis or related disorders, but a clinician must interpret it with symptoms and confirmatory testing.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy