Simvastatin-Dependent Neutrophil IgG Antibody, Serum/Plasma — Qualitative
A qualitative blood test that looks for simvastatin-dependent IgG antibodies reacting with neutrophils, which may help investigate a suspected immune reaction to simvastatin.
["Detection of these antibodies may support simvastatin-related immune-mediated neutropenia."]
Key facts at a glance
- LOINC
- 72952-5
- Short code
- Simvastatin (neut) IgG SerPl Ql FC
- Synonyms
- Simvastatin (neut) IgG SerPl Ql FC
- Category
- liver
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Ref low
- 10
- Ref high
- 40
- Critical range
- — – 500 N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- flow-cytometry
- CPT
- 84484
- SNOMED
- 302774002
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
What is this test?
This test examines serum or plasma for IgG antibodies that react with neutrophils only when simvastatin is present. These are sometimes called drug-dependent neutrophil antibodies.
Why might I need this test?
It may be ordered when a patient develops a low neutrophil count or other signs of an immune reaction while taking simvastatin. Results can help determine whether simvastatin is contributing to the blood-cell problem.
How is the test performed?
A blood sample is collected, and a portion is separated into serum or plasma. A laboratory specialist then tests whether the sample contains simvastatin-dependent neutrophil IgG antibodies.
How do I prepare for the test?
No special preparation is usually required. Tell the healthcare team which medicines you are taking, including the amount of simvastatin and when you last took it, and do not stop prescribed medication without medical advice.
Reference range
Adult: 10-40 U/LN/A
No special preparation required. Avoid fatty meals before the test if possible.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
A positive result means that the sample contains IgG antibodies that react with neutrophils in the presence of simvastatin. This may support a drug-induced immune reaction, including immune-mediated neutropenia, but findings must be interpreted with symptoms, medication history, and other blood-count results. A negative result does not completely rule out a reaction to simvastatin.
Short name
Simvastatin-dependent neutrophil IgG
Frequently asked questions
What does a positive result mean?
Does a negative result rule out simvastatin-related neutropenia?
Should I stop taking simvastatin before the test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy