Serum Immunoglobulin G (IgG) Subclass Analysis (Electrophoresis)
This test measures different types of Immunoglobulin G (IgG) antibodies in your blood, which play a key role in fighting infections and diseases. It helps identify if certain subclasses are too high or too low.
["Understanding your IgG antibody balance can help diagnose or monitor conditions like immune deficiencies, autoimmune diseases, or infections."]
Key facts at a glance
- LOINC
- 66880-6
- Short code
- Skin Ab.IgG pattern Ser Monkey esoph-Imp
- Synonyms
- Skin Ab.IgG pattern Ser Monkey esoph-Imp
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Ref low
- 0
- Ref high
- 17
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- monkey-esophagus-substrate
- CPT
- 82784
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why This Test Is Done
Your healthcare provider may order this test if you have symptoms of an immune system issue, such as frequent infections, unusual fatigue, or unexplained rashes. It may also be used to monitor treatment responses in conditions like lupus, rheumatoid arthritis, or certain infections.
What to Expect Before the Test
No special preparation is needed. You’ll provide a blood sample, usually drawn from a vein in your arm. If you’re on blood thinners, let your provider know before the test.
What the Results Mean
IgG antibodies are divided into four subclasses (IgG1, IgG2, IgG3, IgG4). Abnormal levels in any subclass can indicate immune system dysfunction, allergic reactions, or certain diseases. Your results will be compared to standard reference ranges for your age and health status.
Common Conditions Monitored
This test helps diagnose or track conditions like common variable immunodeficiency, autoimmune diseases (e.g., systemic lupus erythematosus), chronic infections, or allergic disorders. It may also be used to assess immune responses to vaccines.
Reference range
NCBI: NSE 0-17 ng/mLN/A
No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
IgG subclass levels can reveal whether your immune system is producing the right types of antibodies to fight pathogens. Low levels of certain subclasses may suggest a weakened immune response, while elevated levels could indicate overactive immune reactions or certain cancers (e.g., multiple myeloma). Early detection can guide treatment decisions.
Short name
IgG Subclass Profile
Frequently asked questions
What does an abnormal IgG subclass result mean?
How often will I need this test?
Can diet or supplements affect IgG subclass levels?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy