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Skin Integrity and Subcutaneous Fluid Analysis (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test evaluates markers related to skin health and fluid balance in your blood, potentially assessing conditions like dehydration, inflammation, or metabolic disorders.

Quick summary

["Understanding your skin’s fluid and health status can help identify underlying issues affecting your body."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
104832-1
Short code
Skin IgG Ser Ql Human split skin sub
Synonyms
Skin IgG Ser Ql Human split skin sub
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
1.5
Ref high
9
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
human-split-skin-substrate
CPT
83002
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

This test includes measurements of substances that may reflect skin hydration, protein balance, or metabolic processes. Specific analytes could include electrolytes, proteins, or markers of cellular function in subcutaneous tissues.

Why It Matters in Skin Health

Skin integrity depends on proper fluid balance, protein levels, and metabolic support. Abnormal findings might indicate dehydration, protein loss, or systemic conditions like kidney disease or infections.

Sample Collection and Preparation

A blood sample is drawn from a vein, usually in your arm. The serum or plasma is separated for testing. This process is quick and typically done in a clinical setting.

Common Conditions Monitored

This test may be used to monitor conditions like severe dehydration, chronic skin conditions, or metabolic imbalances that affect fluid retention or protein synthesis in tissues.

Reference range

Follicular: 1.5-9.0 mIU/mLN/A

Specimen: serum

For females: inform if menstrual cycle status. For certain tests, timing within menstrual cycle may matter.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Skin and Subcutaneous Fluid Profile

Frequently asked questions

How often will I need this test?
The frequency depends on your health status, treatment plan, or symptoms. Your healthcare provider will determine how often this test is needed based on your individual care plan.
What does a high or low result mean?
Results can indicate fluid or protein imbalances, but they are interpreted in the context of your overall health. Elevated or low levels may signal dehydration, inflammation, or metabolic issues, but your doctor will discuss findings with you.
Can I prepare for this test?
No special preparation is usually needed, but avoid heavy meals or excessive fluids 2–4 hours before the test if instructed by your provider.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy