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Cystatin C, Serum Concentration (Quantitative)

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of cystatin C, a protein produced by all cells in the body. It helps assess kidney function and can be useful in monitoring chronic kidney disease.

Quick summary

["Cystatin C is a simple blood test to check kidney health."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
53724-1
Short code
SLC26A4 p.T416P Bld Ql
Synonyms
SLC26A4 p.T416P Bld Ql
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Ref low
4.5
Ref high
12
Critical range
— – 5 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
molgen
CPT
85610
SNOMED
396252006
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test if you have symptoms of kidney problems, such as fatigue, swelling, or frequent urination. It’s also used to monitor kidney function in people with diabetes, high blood pressure, or other conditions that can affect the kidneys over time. Sometimes, it’s used alongside other tests to better evaluate kidney function, especially in cases where traditional kidney function tests (like creatinine) might not be reliable.

How Is the Test Performed?

A small blood sample is taken from a vein, usually in your arm. The blood is sent to a lab where it is analyzed to measure cystatin C levels. The result is typically available within a few days.

What Do the Results Mean?

Higher than expected cystatin C levels may indicate kidney problems, including reduced kidney function. Lower levels might suggest other health conditions or medications that affect protein production. Your healthcare provider will interpret the results in the context of your overall health and other tests.

Common Causes of Abnormal Results

Elevated cystatin C levels can be caused by kidney disease, infections, muscle disorders, or certain medications. Lower levels may be linked to conditions that reduce protein production or certain genetic factors. Always discuss any changes in your results with your doctor.

Reference range

Adult: 4.5-12.0 μg/dLN/A

Specimen: whole-blood

Take your thyroid medication after the blood draw if applicable. No fasting required.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Cystatin C

Frequently asked questions

What if I have questions about my results?
Cystatin C is often used as a more accurate marker of kidney function than creatinine alone, especially in people with low muscle mass or certain genetic conditions. It can also be helpful in detecting kidney disease at earlier stages. Your doctor may use it to guide treatment decisions, such as adjusting medications or monitoring disease progression.
How often should I get this test?
The frequency depends on your health condition and treatment plan. If you have kidney disease or are at risk, your doctor may recommend regular testing to track changes over time. Follow their advice closely.
Can I eat or drink anything before the test?
No special preparation is needed for this blood test. However, always follow your healthcare provider’s instructions, as some tests may require fasting or other restrictions.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy