OATP1B1 (Slcop1b1) Gene Mutation Screening (Qualitative)
This test checks for mutations in the OATP1B1 gene, which plays a role in how certain medications are processed in your liver. It may be used if you have a family history of liver disease or are considering medications that interact with this gene.
["This test helps assess genetic variations that could affect liver drug metabolism."]
Key facts at a glance
- LOINC
- 104287-8
- Short code
- SLCO1B1 gene.c.521T>C Bld/T Ql
- Synonyms
- SLCO1B1 gene.c.521T>C Bld/T Ql
- Category
- chemistry
- Sample
- whole-blood
- Container
- Lavender-top (EDTA)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- molgen
- Specimen volume
- 3 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h
- Hemolysis max
- 0
- Lipemia max
- 0
- Icterus max
- 0
- TAT
- 4–24 hours
- Order
- routine
Why This Test Might Be Ordered
Your healthcare provider may recommend this test if you have a family history of conditions like non-alcoholic fatty liver disease (NAFLD), liver cirrhosis, or if you’re prescribed medications that are metabolized by the OATP1B1 transporter, such as statins or certain cancer drugs. It can also be part of genetic counseling for conditions linked to liver function.
What to Expect Before the Test
No special preparation is needed for this test. You may provide a blood sample (whole blood) or a saliva sample, depending on the lab’s protocol. If blood is used, it’s typically drawn from a vein in your arm.
What the Results Mean
Results will identify whether you carry specific mutations in the OATP1B1 gene. These mutations can influence how your body processes certain medications, potentially affecting their safety or effectiveness. Your provider will discuss the implications with you based on your medical history and treatment plan.
Common Medications Affecting This Gene
Medications metabolized by OATP1B1 include statins (e.g., atorvastatin, rosuvastatin), some chemotherapy drugs (e.g., docetaxel), and certain antiviral therapies. If you’re prescribed these, your provider may recommend monitoring or dose adjustments based on your genetic results.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Mutations in the OATP1B1 gene can lead to reduced liver function in metabolizing drugs, increasing the risk of side effects or drug resistance. For example, certain genetic variations may require lower doses of statins to avoid liver toxicity. This test is particularly relevant for patients with pre-existing liver conditions or those taking medications known to interact with this transporter.
Short name
OATP1B1 Gene Test
Frequently asked questions
What does a positive result mean?
Will this test change my medication?
Is this test covered by insurance?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy