OATP1B1 Gene Mutation Screening (Serum/Plasma)
This test checks for genetic variations in the OATP1B1 gene, which may affect how your body processes certain medications or metabolic substances.
["Genetic mutations in OATP1B1 can influence drug metabolism and liver function, sometimes requiring personalized medical care."]
Key facts at a glance
- LOINC
- 93412-5
- Short code
- SLCO1B1 Mut Anl Bld/T
- Synonyms
- SLCO1B1 Mut Anl Bld/T
- Category
- chemistry
- Sample
- whole-blood
- Container
- Lavender-top (EDTA)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- molgen
- Specimen volume
- 3 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h
- Hemolysis max
- 0
- Lipemia max
- 0
- Icterus max
- 0
- TAT
- 4–24 hours
- Order
- routine
What This Test Measures
The OATP1B1 gene encodes a protein involved in transporting bile acids and some medications into the liver. Mutations in this gene can alter how efficiently your body processes these substances, potentially affecting liver health or drug effectiveness.
Why It Might Be Ordered
Your healthcare provider may recommend this test if you have a family history of liver disease, certain genetic conditions, or if you’re prescribed medications that rely on liver transport systems (e.g., statins, some chemotherapy drugs). It may also be part of a broader genetic screening process.
What to Expect Before the Test
No special preparation is typically needed. You’ll provide a blood sample (serum or plasma) during a routine clinic visit. If you’re taking medications, let your provider know before the test.
What the Results Mean
Results will identify whether you have specific mutations in the OATP1B1 gene. These mutations can influence how your body handles medications or metabolic processes, which may require adjustments to your treatment plan.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
◆Associated findings1
Short name
OATP1B1 Mutation Test
Frequently asked questions
Will this test affect my medication?
How long will I need to wait for results?
Does this test require fasting?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy