Serum or plasma total bilirubin concentration (direct method)
This test measures the total amount of bilirubin in your blood, a yellow pigment produced when red blood cells break down. It helps assess liver function and detect conditions like jaundice or bile duct blockages.
["Your doctor may order this test to check liver health or identify causes of yellowing skin/high bilirubin levels."]
Key facts at a glance
- LOINC
- 24276-8
- Short code
- SLEV Ab sp2 Titr Ser
- Synonyms
- SLEV Ab sp2 Titr Ser
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why This Test Is Done
Doctors often request total bilirubin tests when symptoms like jaundice (yellowing of skin/eyes), dark urine, pale stools, or unexplained fatigue appear. It may also be part of routine liver function checks or before certain surgeries or treatments.
What to Expect Before the Test
No special preparation is needed, but avoid alcohol for 24 hours before testing. You may have blood drawn from a vein in your arm, which can cause slight discomfort but is quick.
What the Results Mean
Higher than normal levels may signal liver disease, bile duct issues, or red blood cell disorders. Lower levels are less common but could indicate certain blood disorders. Your doctor will interpret results in the context of your health history.
Common Conditions Linked to Bilirubin Levels
Elevated bilirubin is often linked to liver problems (e.g., hepatitis, cirrhosis), blockages in the bile ducts, or hemolytic anemia (rapid red blood cell breakdown). Low levels are rare but may occur with certain blood disorders or liver disease.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
This test is critical for diagnosing and monitoring liver diseases, bile duct obstructions, and conditions affecting red blood cell breakdown. It helps guide treatment plans for jaundice, gallbladder issues, or inherited disorders like Gilbert’s syndrome.
Short name
Total bilirubin
Frequently asked questions
What causes bilirubin to rise in my blood?
How long does it take to get my results?
Can I eat or drink before this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy