Skip to content

Serum Immunoassay for Anti-Double-Stranded DNA Antibodies (Anti-dsDNA)

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of antibodies in your blood that target double-stranded DNA, often linked to autoimmune conditions like lupus.

Quick summary

["Helps diagnose or monitor autoimmune diseases affecting your immune system’s response to your body’s own cells."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
105681-1
Short code
S. mitis DNA Spec Ql NAA+probe
Synonyms
S. mitis DNA Spec Ql NAA+probe
Category
coagulation
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test if you have symptoms of autoimmune diseases, such as unexplained fatigue, joint pain, or skin rashes. It may also be used to check for lupus or other connective tissue disorders.

What to Expect Before the Test

No special preparation is needed. You’ll provide a blood sample, typically drawn from your arm. If you’re on blood thinners, let your provider know before the test.

What the Results Mean

Higher-than-normal levels may suggest an autoimmune condition, but results alone don’t confirm a diagnosis. Your provider will review them alongside other symptoms and tests.

Common Conditions Monitored

This test is often used to diagnose or track lupus, Sjögren’s syndrome, or other autoimmune disorders where the body attacks its own DNA.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Anti-dsDNA Antibody Test

Frequently asked questions

What does a positive result mean?
A positive result suggests an increased likelihood of an autoimmune condition, but further testing and evaluation are needed to confirm a diagnosis. Your provider will discuss next steps based on your symptoms and other test results.
Can lifestyle changes affect this test?
Generally, lifestyle factors like diet or stress may influence autoimmune symptoms but are unlikely to directly alter test results. Avoiding blood thinners before the test is important to ensure accurate results.
How often will I need this test?
Frequency depends on your condition and treatment plan. Your provider may recommend retesting periodically to monitor disease progression or response to treatment.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy