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Smooth Muscle Antibody Profile (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test measures antibodies that may indicate an autoimmune response targeting smooth muscle proteins, often linked to certain liver conditions.

Quick summary

["Autoimmune liver issues may be detected with this test."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
110752-3
Short code
Smooth muscle Ab Msmt Ser
Synonyms
Smooth muscle Ab Msmt Ser
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is This Test For?

Smooth muscle antibodies are part of a broader autoimmune evaluation. They help identify conditions like autoimmune hepatitis or other connective tissue disorders that may affect organs like the liver, heart, or lungs. This test is not specific to one disease but can support a diagnosis when combined with clinical findings and other tests.

Why Might You Need This Test?

Your healthcare provider may order this test if you have symptoms like unexplained fatigue, liver problems (e.g., jaundice, abdominal pain), or other autoimmune symptoms. It may also be used during routine monitoring for autoimmune conditions.

How Is the Sample Collected?

A blood sample is drawn from a vein, usually in your arm. You may feel a small pinch, but it typically doesn’t cause significant discomfort. The sample is sent to a lab for testing.

What to Expect Before or After Testing

No special preparation is needed for this test. You can continue your normal activities. If you’re on blood thinners or have a history of bleeding disorders, let your provider know before the test.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Smooth Muscle Antibodies

Frequently asked questions

What Does a Positive or Negative Result Mean?
A positive result means your blood contains antibodies against smooth muscle proteins, which may indicate an autoimmune condition. However, not everyone with these antibodies has a disease. Your provider will consider your symptoms, other test results, and medical history to determine next steps.
How Often Should I Get This Test?
The frequency depends on your medical needs. Your healthcare provider will decide based on your symptoms, diagnosis, or ongoing treatment. Follow-up may include additional tests or monitoring.
Can This Test Be Done at Home?
No, this test requires a blood sample collected in a clinical setting. Home-based tests for autoimmune markers are not standard for smooth muscle antibodies.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy