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Serum Angiotensin-Converting Enzyme (sACE) Activity

Published: August 9, 2026Updated: August 16, 2026

This test measures the activity level of angiotensin-converting enzyme (ACE) in your blood serum. ACE plays a role in regulating blood pressure and fluid balance, and elevated levels may be linked to certain lung or lymphatic conditions.

Quick summary

["ACE activity helps assess conditions affecting lung or lymphatic systems."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
32945-8
Short code
SNA Angle Skull XR
Synonyms
SNA Angle Skull XR
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
xr-measured
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test if you have symptoms like persistent cough, shortness of breath, or swelling in your legs or abdomen. It may also be used to monitor conditions like lymphangioleiomyomatosis (LAM) or certain infections that affect ACE levels.

What Does the Result Mean?

Results can vary based on your health status and the reason for testing. Elevated ACE levels might suggest conditions like sarcoidosis, certain infections, or lymphatic diseases. Lower levels could indicate other health concerns or normal variations. Always discuss your results with your doctor.

How Is This Test Performed?

A blood sample is drawn from a vein, usually in your arm. The blood is then processed to measure ACE activity using a specialized laboratory method. You may feel a small pinch during the draw, but it typically takes a few minutes to complete.

What Should You Do Before the Test?

No special preparation is usually needed, but inform your doctor about any medications you’re taking, especially those affecting blood pressure or heart function. Avoid strenuous activity or eating heavy meals before the test if instructed.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

sACE

Frequently asked questions

What Are Common Causes of Abnormal Results?
Elevated ACE levels may be associated with conditions like sarcoidosis, certain infections (e.g., tuberculosis), lymphatic diseases (e.g., LAM), or exposure to certain medications. Low ACE levels could be due to liver disease, kidney problems, or other metabolic factors. Always consult your healthcare provider for interpretation.
How Often Should I Get This Test?
The frequency depends on your medical condition and treatment plan. If you have an ongoing health issue linked to ACE, your doctor may recommend regular monitoring. Follow their guidance closely.
Does This Test Have Any Risks or Side Effects?
Minor risks include bruising, slight pain, or swelling at the injection site. Rarely, there may be a reaction to the blood draw, such as fainting or a small blood clot. Most side effects are mild and temporary.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy