Skip to content

Serum or Plasma Alpha-1 Antitrypsin Mass Concentration

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of Alpha-1 Antitrypsin, a protein produced by the liver that helps protect the lungs from damage caused by enzymes released during inflammation.

Quick summary

["Alpha-1 Antitrypsin helps prevent lung disease and liver damage; low levels may indicate genetic deficiency or liver disease."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
98641-4
Short code
SNAP area AUC L MACN
Synonyms
SNAP area AUC L MACN
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
nerve-conduction
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your doctor may order this test if you have symptoms like chronic cough, shortness of breath, or liver problems. It’s also used to diagnose or monitor Alpha-1 Antitrypsin Deficiency, a genetic condition that can lead to lung diseases like emphysema or chronic obstructive pulmonary disease (COPD).

What to Expect Before the Test

No special preparation is needed. You’ll provide a blood sample, usually drawn from your arm. If you’re taking blood thinners, let your doctor know to avoid excessive bleeding.

What the Results Mean

Results help determine if your Alpha-1 Antitrypsin levels are low, which could mean you have a genetic deficiency or another condition affecting protein production. Your doctor will compare your results to standard ranges and discuss them with you.

Common Conditions Linked to Low Levels

Low Alpha-1 Antitrypsin levels are most commonly linked to Alpha-1 Antitrypsin Deficiency, which can cause lung diseases or liver cirrhosis. Other conditions, like chronic liver disease, may also reduce its production.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Alpha-1 Antitrypsin Level

Frequently asked questions

How often will I need this test?
Your doctor will decide how often you need retests based on your symptoms, medical history, and test results. For Alpha-1 Antitrypsin Deficiency, monitoring may occur yearly or more frequently if you have active lung or liver issues.
What if my results are outside the normal range?
If your levels are low, your doctor may recommend further testing, like genetic screening, or suggest lifestyle changes to manage symptoms. High levels may not need immediate action but should be tracked over time for liver health.
Can I eat or drink before this test?
You can eat and drink normally unless instructed otherwise. Avoid alcohol before testing, as it may affect liver-related results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy