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Cerebrospinal Fluid (CSF) Protein Profile by Electrophoresis

Published: August 9, 2026Updated: August 16, 2026

This test measures the different types of proteins found in your cerebrospinal fluid (the fluid surrounding your brain and spinal cord) using electrophoresis, a method that separates proteins based on size and charge.

Quick summary

["Helps identify abnormal protein patterns that may indicate conditions like multiple sclerosis, infections, or tumors."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
60594-9
Short code
Sn-Me'/Face all Skull XR
Synonyms
Sn-Me'/Face all Skull XR
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
0
Ref high
5
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
xr-measured
CPT
82378
SNOMED
394995008
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is This Test Used For?

Electrophoresis in CSF helps doctors distinguish between normal protein distribution and patterns that suggest underlying health issues. For example, it can reveal elevated levels of immunoglobulin G (IgG) in conditions like multiple sclerosis or Guillain-Barré syndrome, or unusual protein spikes that may indicate tumors or infections.

How Is This Test Performed?

A small amount of CSF is collected through a spinal tap (lumbar puncture). The fluid is then processed in a lab to separate proteins by size and charge. The results are displayed as bands or peaks representing different protein types.

Preparation for the Test

No special preparation is needed, but you may be asked to fast or avoid certain medications for 24 hours before the procedure. Your doctor will provide specific instructions based on your health status.

What to Expect During the Procedure

A spinal tap involves inserting a needle into your lower back to collect CSF. You may feel pressure or mild discomfort, but the procedure is usually quick and done under local anesthesia. You’ll need to lie still for a short time afterward.

Reference range

Non-smokers: <2.5 ng/mL; Smokers: <5.0 ng/mLN/A

Specimen: serum

No special preparation required. For PSA, avoid sexual activity for 24-48 hours before the test.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

CSF Protein Electrophoresis

Frequently asked questions

Why might my doctor order this test?
Your doctor may order this test to investigate symptoms like headaches, neurological issues, or unexplained weakness. It helps diagnose conditions such as meningitis, encephalitis, or central nervous system tumors by revealing abnormal protein patterns or cell counts in the CSF.
What are the most common reasons for abnormal results?
Abnormal results may indicate infections (e.g., bacterial or viral meningitis), inflammatory diseases (e.g., multiple sclerosis), or tumors (e.g., lymphoma). Elevated protein levels or specific protein bands can point to these conditions, but further testing is needed for a diagnosis.
How long does it take to get results?
Results are typically available within 24 to 48 hours, depending on lab processing times. Your doctor will discuss the findings with you during a follow-up visit.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy