Skip to content

Chloride concentration (serum/plasma)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of chloride ions in your blood plasma or serum, which helps assess your body’s electrolyte balance and kidney function.

Quick summary

["Chloride helps maintain fluid balance and nerve function; low or high levels may signal health concerns."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
26761-7
Short code
Sodium Cl 2h Ur+SerPl-vRate
Synonyms
Sodium Cl 2h Ur+SerPl-vRate
Category
electrolyte
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
136
Ref high
145
Critical range
120 N/A – 160 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
84295
SNOMED
110741000
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

This test measures the amount of chloride, an important electrolyte, in your blood. It is often done as part of a basic or comprehensive metabolic panel to check your body's fluid balance, hydration, and acid-base status.

Doctors may order a chloride test to check for conditions like dehydration, kidney disease, heart problems, or metabolic imbalances. It’s often done alongside sodium tests to evaluate overall electrolyte health.

Usually, no special preparation is needed for this test. If it is part of a larger panel, you may be asked to fast for several hours beforehand. Tell your doctor about all medicines and supplements you take, and drink water normally unless instructed otherwise.

No special preparation is needed unless instructed. You may drink water but avoid eating or smoking for a few hours before the blood draw. If you’re on a urine test, follow your provider’s instructions for hydration and timing.

A healthcare professional will clean the skin on your arm, wrap a band around your upper arm, and draw a small sample of blood from a vein. The sample is sent to a laboratory, and your results are usually ready within a day or two.

Blood is drawn from a vein (usually in your arm) and sent to a lab. Plasma or serum is analyzed to measure chloride concentration using a specialized method like ion-selective electrode testing or automated chemistry analysis.

Normal chloride levels for adults typically fall between 96 and 106 mEq/L, although exact ranges can vary slightly from one laboratory to another. Your doctor will interpret your value together with other electrolytes, such as sodium and potassium, to understand what it means for you.

Results are reported in millimoles per liter (mmol/L). While exact ranges vary by lab, typical values fall between lower and upper limits that help identify deviations from normal electrolyte balance.

Reference range

Adult: 136-145 mmol/LN/A

Specimen: serum

No special preparation required. Stay well hydrated.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Serum/plasma chloride level

Frequently asked questions

Low chloride levels (hypochloremia) may indicate dehydration, kidney issues, or excessive vomiting/diarrhea. High chloride levels (hyperchloremia) can signal conditions like kidney failure, metabolic acidosis, or overuse of certain medications.
What does a low chloride level mean, and what conditions or medicines can cause chloride to fall below the normal range?
A low chloride level could signal dehydration from vomiting, diarrhea, or excessive sweating. It may also be linked to kidney problems or conditions affecting fluid balance, like heart failure. Your doctor will review your symptoms and other test results to determine the cause.
What does a high chloride level mean, and what conditions, such as dehydration or kidney problems, can cause chloride to rise above the normal range?
High chloride levels may result from kidney disease, severe dehydration, or metabolic imbalances (e.g., acidosis). Rarely, it can occur with certain medications or in people with long-term health conditions like liver disease. Your provider will assess your overall health and other tests to guide next steps.
Your doctor will decide how often to check your chloride levels based on your medical history, symptoms, and other tests. Routine adults typically don’t need this test unless they have risk factors (e.g., kidney disease, heart problems) or are taking medications that affect electrolytes.
  1. 1
  2. 2
  3. 3

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy