Skip to content

Sodium concentration in cerebrospinal fluid (CSF)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of sodium, a key mineral, in your cerebrospinal fluid—the fluid that surrounds your brain and spinal cord.

Quick summary

["Sodium levels in CSF help diagnose conditions affecting brain fluid balance."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
2948-8
Short code
Sodium CSF-sCnc
Synonyms
Sodium CSF-sCnc
Category
electrolyte
Sample
csf
Container
Sterile tube
Units
N/A
Ref low
136
Ref high
145
Critical range
120 N/A – 160 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
84295
SNOMED
110741000
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

Why This Test Matters

Sodium is essential for nerve and muscle function, but abnormal levels in CSF can signal issues like inflammation, infections, or structural problems in the brain. Your doctor may order this test if you have symptoms like headaches, neurological deficits, or signs of a condition like meningitis, multiple sclerosis, or brain tumors.

When You Might Need It

This test is often performed when evaluating symptoms such as severe headaches, seizures, confusion, or weakness that may suggest abnormal fluid pressure or brain inflammation. It’s also used in diagnosing conditions like idiopathic intracranial hypertension (pseudotumor cerebri) or certain types of brain swelling.

What to Expect Before the Test

No special preparation is needed. A healthcare provider will collect a small sample of CSF through a procedure called a lumbar puncture (spinal tap), where a needle is inserted into your lower back to draw fluid from the spinal canal.

What the Results Mean

Results are compared to standard ranges for sodium in CSF, which can vary slightly by lab. Low sodium levels (hyponatremia) may indicate conditions like meningitis or brain edema, while high levels (hypernatremia) could suggest bleeding, tumors, or other structural abnormalities.

Reference range

Adult: 136-145 mmol/LN/A

Specimen: csf

No special preparation required. Stay well hydrated.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

CSF Sodium

Frequently asked questions

What causes abnormal sodium levels in CSF?
Abnormal sodium levels in CSF can result from infections (like meningitis), inflammatory diseases (such as multiple sclerosis), brain tumors, or conditions causing abnormal fluid production or leakage. Your doctor will consider your symptoms, medical history, and other test results to interpret the results accurately.
How long will I need to wait for results?
Results are typically available within a few days, depending on your lab’s processing time. Your healthcare provider will discuss the findings with you during your follow-up visit.
Can I eat or drink before this test?
No dietary restrictions apply for this test. However, inform your healthcare provider about any medications you’re taking, as some may affect fluid balance or the procedure.
  1. 1
  2. 2
  3. 3

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy