Sodium concentration in cerebrospinal fluid (CSF)
This test measures the amount of sodium, a key mineral, in your cerebrospinal fluid—the fluid that surrounds your brain and spinal cord.
["Sodium levels in CSF help diagnose conditions affecting brain fluid balance."]
Key facts at a glance
- LOINC
- 2948-8
- Short code
- Sodium CSF-sCnc
- Synonyms
- Sodium CSF-sCnc
- Category
- electrolyte
- Sample
- csf
- Container
- Sterile tube
- Units
- N/A
- Ref low
- 136
- Ref high
- 145
- Critical range
- 120 N/A – 160 N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- CPT
- 84295
- SNOMED
- 110741000
- Specimen volume
- 1-2 mL
- Stability
- Immediate analysis required, Refrigerated: 1h
- Hemolysis max
- 200
- TAT
- 4–24 hours
- Order
- routine
Why This Test Matters
Sodium is essential for nerve and muscle function, but abnormal levels in CSF can signal issues like inflammation, infections, or structural problems in the brain. Your doctor may order this test if you have symptoms like headaches, neurological deficits, or signs of a condition like meningitis, multiple sclerosis, or brain tumors.
When You Might Need It
This test is often performed when evaluating symptoms such as severe headaches, seizures, confusion, or weakness that may suggest abnormal fluid pressure or brain inflammation. It’s also used in diagnosing conditions like idiopathic intracranial hypertension (pseudotumor cerebri) or certain types of brain swelling.
What to Expect Before the Test
No special preparation is needed. A healthcare provider will collect a small sample of CSF through a procedure called a lumbar puncture (spinal tap), where a needle is inserted into your lower back to draw fluid from the spinal canal.
What the Results Mean
Results are compared to standard ranges for sodium in CSF, which can vary slightly by lab. Low sodium levels (hyponatremia) may indicate conditions like meningitis or brain edema, while high levels (hypernatremia) could suggest bleeding, tumors, or other structural abnormalities.
Reference range
Adult: 136-145 mmol/LN/A
No special preparation required. Stay well hydrated.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Clinical Significance
Short name
CSF Sodium
Frequently asked questions
What causes abnormal sodium levels in CSF?
How long will I need to wait for results?
Can I eat or drink before this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy