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Salicylate concentration in serum/plasma

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of salicylate (aspirin-related compound) in your blood, often checked after ingestion of aspirin or other salicylate-containing medications.

Quick summary

["Salicylate levels help assess toxicity or therapeutic dosing of salicylates."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
48292-7
Short code
Sodium salicylate LR-mCnc
Synonyms
Sodium salicylate LR-mCnc
Category
electrolyte
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
136
Ref high
145
Critical range
120 N/A – 160 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
84295
SNOMED
110741000
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test if you’ve taken high doses of aspirin or other salicylates (e.g., for pain, fever, or inflammation) and suspect overdose. It may also be used to monitor long-term use in certain conditions, like rheumatoid arthritis.

What to Expect Before the Test

No special preparation is needed. You’ll provide a blood sample, usually drawn from your arm. If you’re on salicylate medications, inform your provider before testing to avoid misleading results.

What the Results Mean

Salicylate levels above normal can indicate toxicity (e.g., nausea, ringing ears, confusion). Very high levels may require urgent medical attention. Lower-than-expected levels could mean poor absorption or drug interactions.

Common Causes and Risks

Overdosing on aspirin or other salicylates (e.g., from accidental ingestion) is the most common cause. Rarely, conditions like salicylate hypersensitivity or kidney issues may affect results.

Reference range

Adult: 136-145 mmol/LN/A

Specimen: serum

No special preparation required. Stay well hydrated.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Salicylate Level

Frequently asked questions

How long does it take to get results?
Results are typically available within 1–2 business days, depending on your lab. Follow-up may be needed if levels are abnormal.
Can I drink water before the test?
Yes, you can drink water unless instructed otherwise. Avoid alcohol or caffeine before testing, as they may affect blood composition.
What if I missed my last dose of salicylate medication?
If you missed a dose, your provider may adjust testing timing or use a different method to assess exposure. Always report your medication history to your lab.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy