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Insulin-like Growth Factor 1 (IGF-1) Serum

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of IGF-1, a hormone produced by the liver in response to growth hormone from the pituitary gland. It plays a key role in growth, cell repair, and metabolism.

Quick summary

["IGF-1 helps regulate growth and development, often checked in children with growth concerns or adults with suspected hormonal imbalances."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
2486-9
Short code
Somatomedins SerPl-mCnc
Synonyms
Somatomedins SerPl-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is IGF-1 Used For?

IGF-1 is primarily used to assess growth and development in children, diagnose conditions affecting growth hormone production, and monitor treatment responses in conditions like growth hormone deficiency or acromegaly. It may also be evaluated in adults with suspected metabolic or endocrine disorders.

How Is the Test Performed?

A blood sample is drawn from a vein, usually in your arm. The sample is sent to a lab where it is processed to measure IGF-1 levels using a specialized immunoassay method. Results are compared to reference ranges appropriate for your age and sex.

Why Might You Need This Test?

You may need an IGF-1 test if you have concerns about slow growth in children, unexplained short stature, or symptoms like delayed puberty. In adults, it could be ordered for suspected growth hormone disorders, metabolic issues, or monitoring treatment for conditions like pituitary tumors.

What Do My Results Mean?

Results are interpreted by your healthcare provider based on your age, medical history, and symptoms. Low IGF-1 may indicate growth hormone deficiency, while high levels could suggest acromegaly or other metabolic conditions. No absolute reference ranges are provided here; your provider will discuss findings with you.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

IGF-1

Frequently asked questions

Why do some people get this test during pregnancy?
IGF-1 is not typically measured during pregnancy unless there are specific clinical concerns, such as suspected fetal growth restriction or maternal conditions affecting growth hormone regulation. Your doctor would discuss this individually.
What if my IGF-1 level is outside the expected range?
If your IGF-1 level is abnormal, your healthcare provider will review your symptoms, medical history, and other test results to determine the cause. Possible causes include genetic disorders, thyroid issues, or hormonal imbalances. Treatment may involve hormone therapy or other interventions tailored to your condition.
Can diet or lifestyle affect IGF-1 levels?
Dietary factors like protein intake, vitamin D levels, and overall nutrition can influence IGF-1, but results are typically interpreted in the context of your overall health. Lifestyle habits such as exercise and weight management may also play a role, though they are not the sole determinants of test results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy