Serum or Plasma Substance Concentration (Bromocresol Green Dye Binding)

What This Test Measures

The bromocresol green (BCG) dye binding test evaluates the concentration of proteins in your blood by measuring how much of the dye binds to these proteins. When the dye binds, it changes color, which is detected and quantified. This process indirectly reflects your body’s protein levels, particularly albumin, which is crucial for maintaining blood pressure and fluid balance.

Why It’s Done

Doctors may order this test to check for liver disease, malnutrition, or kidney problems, as these conditions can affect protein production or retention in the blood. It can also be used to monitor treatment effectiveness for conditions like cirrhosis or protein-losing syndromes.

Sample Collection and Preparation

A blood sample is drawn from a vein, typically in the arm. The sample is then processed to separate serum or plasma, where the dye binding assay is performed. The test does not require fasting unless specified by your healthcare provider.

Common Conditions Monitored

This test is often used alongside other liver function tests to diagnose or monitor conditions such as liver disease, severe malnutrition, or conditions that cause protein loss in the urine (e.g., nephrotic syndrome). It may also be part of a broader evaluation for systemic diseases affecting protein synthesis.