Cerebrospinal Fluid Protein by Immunoassay (Total Protein)
This test measures the total protein content in your cerebrospinal fluid (CSF), the clear fluid that surrounds your brain and spinal cord. It helps assess conditions affecting the brain and nervous system.
["Protein levels in CSF can signal potential neurological issues."]
Key facts at a glance
- LOINC
- 49070-6
- Short code
- Specimen drawn CSF
- Synonyms
- Specimen drawn CSF
- Category
- chemistry
- Sample
- csf
- Container
- Sterile tube
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Specimen volume
- 1-2 mL
- Stability
- Immediate analysis required, Refrigerated: 1h
- Hemolysis max
- 200
- TAT
- 4–24 hours
- Order
- routine
Why Is This Test Done?
Your doctor may order this test to evaluate symptoms such as headaches, vision changes, numbness, weakness, or neurological problems. It can also help diagnose conditions like meningitis, multiple sclerosis, brain tumors, or other inflammatory or infectious processes in the central nervous system.
What to Expect Before the Test
No special preparation is needed. You may have a small needle inserted into your lower back to collect a sample of CSF. This is usually done in a hospital or clinic setting under sterile conditions. You might feel mild pressure or discomfort, but it should not be severe.
What Happens During the Test?
The collected CSF sample is sent to a lab where it is analyzed for total protein levels using an immunoassay method. This test is quick and painless after the initial procedure.
What Are Possible Results?
Results are interpreted by your healthcare provider based on your symptoms and medical history. Elevated protein levels might suggest inflammation, infection, or other neurological conditions, while normal levels help rule out certain issues.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Elevated CSF protein levels can indicate conditions such as multiple sclerosis, meningitis, encephalitis, or brain tumors. Lower-than-expected levels may suggest bleeding or other abnormalities. Your doctor will consider the context of your symptoms and other test results to determine the next steps.
Short name
CSF Protein
Frequently asked questions
What does a high protein level in CSF mean?
How long does it take to get results from this test?
Can I drink or eat before this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy