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C-reactive protein (CRP) with high-sensitivity measurement

Published: August 9, 2026Updated: August 16, 2026

This test measures a protein produced by the liver in response to inflammation, helping doctors assess low-grade inflammation in your body.

Quick summary

["hs-CRP helps track subtle inflammation that may not show up in other tests."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
89631-6
Short code
SPECT+CT Guided WB Tum loc--W RNC IV
Synonyms
SPECT+CT Guided WB Tum loc--W RNC IV
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
nm-spect-ct
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why hs-CRP Matters in Your Health

hs-CRP is a marker for inflammation, which can occur with infections, injuries, or chronic conditions like arthritis or heart disease. Even small amounts of inflammation can signal potential risks for conditions like heart disease or autoimmune disorders.

What Does a High or Low hs-CRP Level Mean?

A higher than normal hs-CRP level may indicate inflammation or increased risk for certain health problems. A lower level suggests less inflammation, but it doesn’t rule out all causes of inflammation.

How Is This Test Performed?

A small blood sample is drawn from your arm. The blood is processed to measure hs-CRP levels using a sensitive immunoassay method, often called chemiluminescent immunoassay (CLIA).

When Might You Need This Test?

Your doctor may order hs-CRP testing if you have symptoms of inflammation, a history of chronic conditions, or if you’re at higher risk for heart disease or other inflammatory diseases.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: hs-CRP plays a role in monitoring chronic conditions, guiding preventive care, and assessing the risk of cardiovascular events. It’s particularly useful for patients with known risk factors or those undergoing treatment for inflammatory diseases.

Short name

hs-CRP (serum/plasma)

Frequently asked questions

What does an elevated hs-CRP level mean for my health?
An elevated hs-CRP level suggests inflammation is present, which may signal an underlying condition like infection, autoimmune disease, or increased cardiovascular risk. Your doctor will discuss this with you and may recommend further testing or lifestyle changes.
Can diet or exercise affect hs-CRP levels?
Yes, lifestyle factors such as diet, exercise, and weight management can influence inflammation levels. Reducing processed foods, increasing omega-3 fatty acids, and staying physically active may help lower hs-CRP levels over time.
How often should I get this test?
Your doctor will determine the frequency based on your health status, symptoms, and risk factors. Regular monitoring may be recommended if you have chronic conditions like heart disease or arthritis.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy