: Sperm Agglutination Titers, Semen

: What Is Being Tested

: The test measures antibodies, typically of the IgA and IgG classes, that bind to sperm and cause them to stick together. The result is reported as a titer, which indicates how dilute the sample must be before agglutination is no longer seen—a higher titer suggests a stronger antibody effect.

: Why the Test Is Ordered

: It is usually ordered as part of a male infertility workup, especially when a semen analysis shows sperm clumping, reduced motility, or unexplained poor sperm function. It may also be used when a couple's fertility problems remain unexplained after routine testing.

: How the Sample Is Collected

: A semen sample is collected, generally after a period of abstinence recommended by the laboratory. The sample is then processed to assess whether antibodies are present and to determine the agglutination titer. Follow your lab's specific collection instructions.

: What the Results Mean

: A low or negative titer generally suggests that sperm antibodies are not a major factor. A higher titer suggests that antibody-related sperm clumping may be present and could affect sperm movement or function. Results are interpreted alongside the semen analysis and the full clinical picture.